Results 61 to 70 of about 4,530,863 (282)

Reconciling global tipping point theories: insight from magnetic experiments

Driven by a combination of global warming and unsustainable resource management, global tipping elements represent existential threats to Earth’s systems and communities. However, the tipping point theory is still developing.
Thompson, Roy, Tooke, K., Dearing, John A., Tooke, Kirsty, Dearing, J. A., Willcock, S., Willcock, Simon, Thompson, R.   +7 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Tipping point for pulsatile oscillations in dynamical networks

Physical Review Research, 2023
Across a tipping point, a stable steady state of a complex system loses its stability, shifting abruptly to an entirely different state due to tiny perturbations on the intrinsic properties or external environment.
Bo-Wei Qin (秦伯韡), Wei Lin (林伟)
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Global tipping points report 2025. Status of Earth system tipping points: what’s new? [Chapter 2.2] [PDF]

The world has entered a new reality. Global warming will soon exceed 1.5°C. This puts humanity in the danger zone where multiple climate tipping points pose catastrophic risks to billions of people.
Aksenov, Yevgeny, Armstrong McKay, David I., Langebroek, Petra M., Hessen, Dag O., Arellano Nava, Beatriz, Nitzbon, Jan, Gunn, Kathryn, Dakos, Vasilis, von der Heydt, Anna, Steinert, Norman J., Sanabria-Fernández, José A., Chiessi, Cristiano M., Flores, Bernardo M., Sakschewski, Boris, Sinet, Sacha, Tharammal, Thejna, Pradal, Marie-Aude, Loriani, Sina, Kéfi, Sonia, Kääb, Andreas, Wunderling, Nico, Abrams, Jesse F., Abis, Beniamino, England, Matthew H., Staver, A. Carla, Duke, Norman C., Brunetti, Maura, Millman, Helen, Sudakow, Ivan, Dennis, Donovan P., Schwinger, Jörg, Garbe, Julius, Spears, Bryan M., Lucarini, Valerio, Parry, Isobel, Buxton, Joshua E., Messori, Gabriele, Pichon, Benoît   +37 more
core   +3 more sources

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Early opportunity signals of a tipping point in the UK's second-hand electric vehicle market [PDF]

Earth System Dynamics
The use of early warning signals to detect the movement of natural systems towards tipping points is well established. Here, we explore whether the same indicators can provide early opportunity signals (EOSs) of a tipping point in a social dataset: views
C. A. Boulton, J. E. Buxton, T. M. Lenton   +2 more
doaj   +1 more source