Results 31 to 40 of about 35,159 (258)

Ineffectiveness of tirzepatide in mitigating Doxorubicin-induced oxidative stress and cognitive deficits in a rat model

open access: yesFrontiers in Pharmacology
Doxorubicin (DXN) is widely utilized for the treatment of various cancer types. However, prolonged DXN administration induces vascular impairment and neurological effects, including cognitive deficits.
Salma A. Alolayan, Ahmad H. Alhowail
doaj   +1 more source

Enzymatic Functions for Toll/Interleukin-1 Receptor Domain Proteins in the Plant Immune System

open access: yesFrontiers in Genetics, 2020
Rationally engineered improvements to crop plants will be needed to keep pace with increasing demands placed on agricultural systems by population growth and climate change.
Adam M. Bayless, Marc T. Nishimura
doaj   +1 more source

Laser‐Induced Graphene from Waste Almond Shells

open access: yesAdvanced Functional Materials, EarlyView.
Almond shells, an abundant agricultural by‐product, are repurposed to create a fully bioderived almond shell/chitosan composite (ASC) degradable in soil. ASC is converted into laser‐induced graphene (LIG) by laser scribing and proposed as a substrate for transient electronics.
Yulia Steksova   +9 more
wiley   +1 more source

A Flexible Metamaterial Absorber via Loss Engineering for Large‐Area Ultra‐Broadband Infrared Extinction

open access: yesAdvanced Science, EarlyView.
Designed and demonstrated a flexible metamaterial absorber via loss engineering for large‐area ultra‐broadband infrared extinction, providing a new method for miniaturization of absorbers and flexible optical devices. ABSTRACT The advancement of compact and wearable optical systems is critically limited by the lack of high‐performance, integrable ...
Zhe Wu   +11 more
wiley   +1 more source

Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions

open access: yesMolecules, 2022
Toll-interleukin receptor (TIR) domains have emerged as critical players involved in innate immune signaling in humans but are also expressed as potential virulence factors within multiple pathogenic bacteria.
Eunjeong Lee   +8 more
doaj   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

open access: yesAdvanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei   +8 more
wiley   +1 more source

High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele

open access: yesBMC Genomics, 2010
Background Trypanosomosis is the most economically important disease constraint to livestock productivity in Africa. A number of trypanotolerant cattle breeds are found in West Africa, and identification of the genes conferring trypanotolerance could ...
Soller Morris   +2 more
doaj   +1 more source

The association between time in the glucose target range and abnormal ankle-brachial index: a cross-sectional analysis

open access: yesCardiovascular Diabetology, 2022
Background Time in range (TIR), a novel proxy measure of glucose control, is found closely related to diabetic microangiopathy and some other chronic complications, but the correlation between TIR and lower limb angiopathy has not been studied yet.
Yinghua Wei   +12 more
doaj   +1 more source

Association between time in range and cancer mortality among patients with type 2 diabetes: a prospective cohort study

open access: yesChinese Medical Journal, 2022
. Background:. Little was known about the association among time in range (TIR), time above range (TAR), time below range (TBR), and cancer mortality among patients with type 2 diabetes.
Yun Shen   +11 more
doaj   +1 more source

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

open access: yesAdvanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu   +6 more
wiley   +1 more source

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