Results 41 to 50 of about 35,214 (259)

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

amo [PDF]

پژوهش در نظام‌های آموزشی, 2013
چکیده نظام آموزش عالی مغز متفکر جامعه و اردوگاه علم جدید است. بدون تردید دانشگاه آزاد اسلامی نقش غیر قابل انکاری در توسع ۀ علمی و پژوهشی کشور ایفا کر ده است، اما در سالهای اخیر این دانشگاه با کاهش تقاضای ورود دانشجو مواجه شده است، این طرح پژوهشی با هدف ...
hada tir
doaj  

The association between time in the glucose target range and abnormal ankle-brachial index: a cross-sectional analysis

Cardiovascular Diabetology, 2022
Background Time in range (TIR), a novel proxy measure of glucose control, is found closely related to diabetic microangiopathy and some other chronic complications, but the correlation between TIR and lower limb angiopathy has not been studied yet.
Yinghua Wei, Chunyan Liu, Yanyu Liu, Zhen Zhang, Zhouqin Feng, Xinyi Yang, Juan Liu, Haiyan Lei, Hui Zhou, Qiuyue Shen, Bin Lu, Ping Gu, Jiaqing Shao   +12 more
doaj   +1 more source

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

TIR over Egyptian Hieroglyphs [PDF]

2016 27th International Workshop on Database and Expert Systems Applications (DEXA), 2016
This work presents an Information Retrieval system specifically designed to manage Ancient Egyptian hieroglyphic texts taking into account their peculiarities at both the lexical and encoding level for its application in Egyptology and Digital Heritage.
Estíbaliz Iglesias-Franjo, Jesús Vilares   +1 more
openaire   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Leveraging Big Multitemporal Multisource Satellite Data and Artificial Intelligence for the Detection of Complex and Invisible Features: The Case of Extensive Irrigation Mapping

Archaeological Prospection, EarlyView.
ABSTRACT The detection of buried or obscured archaeological features remains a central challenge in landscape archaeology, particularly in the irrigated floodplains of Mesopotamia where levees and canals formed the basis of complex agrarian systems. This study presents a deep learning–based approach for the large‐scale, automated detection of ancient ...
Nazarij Buławka, Hector A. Orengo, Felipe Lumbreras Ruiz, Iban Berganzo‐Besga, Ekta Gupta   +4 more
wiley   +1 more source

Outline and Impact of Firms Related to the Third Industrial Revolution: Investigation through Big Data

Smart Cities, 2022
This article is focusing on the dynamism of the Third Industrial Revolution (TIR) in the region Hauts-de-France between 2013 and 2018. Region Hauts-de-France has been a forerunner in setting up a proactive policy in favour of the TIR.
Matthieu Belarouci
doaj   +1 more source

The Role of TIR-NBS and TIR-X Proteins in Plant Basal Defense Responses [PDF]

PLANT PHYSIOLOGY, 2013
Toll/interleukin receptor (TIR) domain-containing proteins encoded in the Arabidopsis (Arabidopsis thaliana) genome include the TIR-nucleotide binding site (TN) and TIR-unknown site/domain (TX) families. We investigated the function of these proteins. Transient overexpression of five TX and TN genes in tobacco (Nicotiana benthamiana) induced chlorosis.
Raja Sekhar, Nandety, Jeffery L, Caplan, Keri, Cavanaugh, Bertrand, Perroud, Tadeusz, Wroblewski, Richard W, Michelmore, Blake C, Meyers   +6 more
openaire   +2 more sources

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source