Results 81 to 90 of about 6,454 (219)

The Voice of a Disease: Why Food Noise Can No Longer Be Ignored!

Obesity, EarlyView.
Abdulhameed Alhazmi, Carel W. le Roux
wiley   +1 more source

Seizure recurrence after GLP‐1 receptor agonist initiation in adults with epilepsy

Epilepsia, EarlyView.
Abstract Objective To examine whether initiation of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) is associated with seizure recurrence and related outcomes in adults with epilepsy and type 2 diabetes. Methods We conducted a retrospective cohort study using de‐identified electronic health records from the TriNetX Research Network (January 2003 ...
Majd A. AbuAlrob, Abdullah Hussein, Rand Abdellatif, Adham Itbaisha, Khaled Zammar, Boulenouar Mesraoua   +5 more
wiley   +1 more source

Predictors of initial and sustained glycemic and weight response to tirzepatide:a post hoc analysis of SURPASS-4 [PDF]

This post hoc analysis assessed sustainability of lowered HbA1c and weight with tirzepatide in people with type 2 diabetes and increased cardiovascular risk.
Del Prato, Stefano, Franco, Denise R., Hemmingway, Andrea, Kahn, Steven E, Nicolay, Claudia, Pavo, Imre, Pearson, Ewan, Wiese, Russell J., Zheng, Junyuan   +8 more
core   +1 more source

Efficacy and Safety of Tirzepatide for Weight Management in Non-Diabetic Obese Individuals: A Narrative Review

Obesities
Obesity represents a global health challenge, with a critical and urgent need for long-term, sustainable management strategies. Tirzepatide is a novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor ...
Mohammed Sallam, Johan Snygg, Sara El Ghandour, Malik Sallam   +3 more
doaj   +1 more source

Tirzepatide in Sport: A Comprehensive Review of its Metabolic Impacts and Potential Applications for Athletes [PDF]

IntroductionTirzepatide, a dual agonist of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors, has emerged as a transformative metabolic therapy with exceptional efficacy in weight management and glycemic control.
Biesiada, Wiktor, Chernysh, Anna-Mariia, Dusińska, Aleksandra, Fuczyło, Kamila, Kmieć, Justyna Weronika, Kopczyńska, Ewelina, Kulej, Piotr, Stankevič, Karolina, Waszczyński, Jakub, Woźniak, Justyna   +9 more
core   +1 more source

Endogenous GIP signaling is indispensable for DPP‐4 inhibitor‐mediated metabolic control in mice

Journal of Diabetes Investigation, EarlyView.
This study reveals that the metabolic benefits of DPP‐4 inhibitors, including improved glucose tolerance and reduced body weight, are completely abolished in GIP receptor‐deficient mice. These findings establish that endogenous GIP signaling, rather than GLP‐1, is the indispensable key player for the efficacy of this drug class.
Saki Kubota‐Okamoto, Sodai Kubota, Hiromi Tsuchida, Yanyan Liu, Seiya Banno, Toshinori Imaizumi, Taro Fujisawa, Yoshihiro Takahashi, Takehiro Kato, Yukio Horikawa, Katsumi Iizuka, Takaaki Murakami, Yuuka Fujiwara, Hitoshi Kuwata, Yuji Yamazaki, Yutaka Seino, Shin Tsunekawa, Daisuke Yabe   +17 more
wiley   +1 more source

Association of baseline characteristics with clinical outcomes of tirzepatide treatment in Japanese patients with obesity disease: A subgroup analysis of the SURMOUNT-J trial. [PDF]

Diabetes Obes Metab
Abstract Aims This analysis aimed to assess the influence of selected baseline factors on tirzepatide treatment response in Japanese patients with obesity disease. Materials and Methods This was a prespecified subgroup analysis of the SURMOUNT‐J trial.
Yokote K, Fukushima Y, Shingaki T, Oura T, Ogawa W.   +4 more
europepmc   +2 more sources

Novel findings regarding treatment obesity and weight-related comorbidities – the systemic literature review [PDF]

Obesity and overweight are a growing health problem worldwide and are recognized as risk factors for many health complications and increased mortality. Therefore, it is necessary to take decisive action to fight the obesity epidemic to avoid significant ...
Baczewski, Mateusz, Czyż, Witold, Grego, Katarzyna, Grego, Mateusz, Kwiatkowski, Filip, Popiela, Dariusz, Stojak, Łukasz, Urbańska, Karina   +7 more
core   +1 more source

The urinary albumin‐to‐creatinine ratio can direct personalized prevention and treatment for cardiovascular and chronic kidney disease

Journal of Internal Medicine, EarlyView.
Abstract Increased urinary albumin excretion is a strong predictor for cardiovascular events in persons with and without decreased glomerular filtration rate and can be assessed with the urinary albumin‐to‐creatinine ratio (UACR), which is a selective, sensitive, and convenient method for patients.
Holly J. Kramer, George L. Bakris
wiley   +1 more source

A real-world disproportionality analysis of tirzepatide-related adverse events based on the FDA Adverse Event Reporting System (FAERS) database

Endocrine Journal
Tirzepatide is a novel drug for the treatment of type 2 diabetes mellitus and chronic weight management, and there is an urgent need to explore its safety profile.
Jie Li, Jun Xie, Yi Han, Wei Zhang, Yilei Wang, Zhitao Jiang   +5 more
doaj   +1 more source