Results 91 to 100 of about 18,381,159 (295)

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Distribution and function of human long-lasting T cells in aging and non-small cell lung cancer

Frontiers in Immunology
T lymphocytes, essential components of the adaptive immune system, orchestrate pathogen-specific responses and long-term immunological memory through heterogeneous subsets with distinct functional properties and spatial distributions.
Jia Xuan Tan, Hua Run Yu, Yong Gu, Hai Hong   +3 more
doaj   +1 more source

Virus-specific immune memory at peripheral sites of herpes simplex virus type 2 (HSV-2) infection in guinea pigs. [PDF]

PLoS ONE, 2014
Despite its importance in modulating HSV-2 pathogenesis, the nature of tissue-resident immune memory to HSV-2 is not completely understood. We used genital HSV-2 infection of guinea pigs to assess the type and location of HSV-specific memory cells at ...
Jingya Xia, Ronald L Veselenak, Summer R Gorder, Nigel Bourne, Gregg N Milligan   +4 more
doaj   +1 more source

Corneal tissue-resident memory T cells form a unique immune compartment at the ocular surface

, 2022
The eye is considered immune privileged such that immune responses are dampened to protect vision. As the most anterior compartment of the eye, the cornea is exposed to pathogens and can mount immune responses that recruit effector T cells.
Schienstock, D, Loi, JK, Chinnery, HR, Senthil, K, Mackay, LK, Sandford, S, Downie, LE, Christo, SN, Sloan, EK, Mueller, SN, Devi, S, Osborne, PB, Alexandre, YO   +12 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Decreased Frequency of Intestinal CD39+ γδ+ T Cells With Tissue-Resident Memory Phenotype in Inflammatory Bowel Disease

Frontiers in Immunology, 2020
The ectoenzymes CD39 and CD73 play a major role in controlling tissue inflammation by regulating the balance between adenosine triphosphate (ATP) and adenosine. Still, little is known about the role of these two enzymes and ATP and its metabolites in the
Jana Libera, Melanie Wittner, Melanie Wittner, Marcus Kantowski, Robin Woost, Robin Woost, Johanna M. Eberhard, Johanna M. Eberhard, Jocelyn de Heer, Dominik Reher, Samuel Huber, Friedrich Haag, Julian Schulze zur Wiesch, Julian Schulze zur Wiesch   +13 more
doaj   +1 more source

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer [PDF]

, 2019
High numbers of tissue-resident memory T (TRM) cells are associated with better clinical outcomes in cancer patients. However, the molecular characteristics that drive their efficient immune response to tumors are poorly understood. Here, single-cell and
Divya Singh, Tilman Sanchez-Elsner, Bhattacharyya, Sourya, Oliver Wood, Awad, Amiera S, Grégory Seumois, Madrigal, Ariel, Friedmann, Peter, Awad, Amiera, Chee, Serena, Jamie Tzu Wen, Singh, Divya, Seumois, Gregory, Sourya Bhattacharyya, Mccann, Katy, Woo, Edwin, Panwar, Bharat, Edwin Woo, Ay, Ferhat, Anusha-Preethi Ganesan, Pandurangan Vijayanand, Ferhat Ay, Gujar, Ravindra, Clarke, James, Christian H. Ottensmeier, Emma V. King, Christopher J. Hanley, Eschweiler, Simon, Simon Eschweiler, Hanley, Christopher, King, Emma, Alzetani, Aiman, Bharat Panwar, Chee, Serena J, Friedmann, Peter S, Vijayanand, Pandurangan, Thomas, Gareth J, Amiera S. Awad, Ottensmeier, Christian, Gareth J. Thomas, McCann, Katy J, Wood, Oliver, Thomas, Gareth, Ottensmeier, Christian H, Serena J. Chee, Aiman Alzetani, King, Emma V, Sanchez-Elsner, Tilman, Ganesan, Anusha-Preethi, Katy J. McCann, Hanley, Christopher J, Ariel Madrigal, Ravindra Gujar, James Clarke, Peter S. Friedmann   +53 more
core   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Spatial organization of tissue-resident memory T cells

Immunity
Tissue-resident memory T (TRM) cells durably reside in peripheral tissues, poised to deliver rapid local immune protection. TRM cells are found in most organs, and they are a core component of immunological memory, complementing circulating memory T cell populations.
Thomas N, Burn, Laura K, Mackay
openaire   +2 more sources

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source