Results 111 to 120 of about 18,381,159 (295)

Tissue-resident memory CD8+ T cells amplify anti-tumor immunity by triggering antigen spreading through dendritic cells

Nature Communications, 2019
Immunotherapy can induce antigen spreading of antitumor T cell response, which correlates with better outcomes. Here the authors show that tissue-resident memory CD8 T cells promote antigen spreading via lysing tumor cells and promoting their uptake and ...
Evelyn Menares, Felipe Gálvez-Cancino, Pablo Cáceres-Morgado, Ehsan Ghorani, Ernesto López, Ximena Díaz, Juan Saavedra-Almarza, Diego A. Figueroa, Eduardo Roa, Sergio A. Quezada, Alvaro Lladser   +10 more
doaj   +1 more source

Lung Tissue Resident Memory T-Cells in the Immune Response to Mycobacterium tuberculosis

Frontiers in Immunology, 2019
Despite widespread BCG vaccination and effective anti-TB drugs, Tuberculosis (TB) remains the leading cause of death from an infectious agent worldwide.
Paul Ogongo, Paul Ogongo, Paul Ogongo, James Zachary Porterfield, James Zachary Porterfield, James Zachary Porterfield, Alasdair Leslie, Alasdair Leslie   +7 more
doaj   +1 more source

Antigen-Specific CD4+ T Cells Exhibit Distinct Kinetic and Phenotypic Patterns During Primary and Secondary Responses to Infection

Frontiers in Immunology, 2020
Although CD4+ T cell memory is a critical component of adaptive immunity, antigen-specific CD4+ T cell recall responses to secondary infection have been inadequately studied.
Deepali Malhotra, Kristina S. Burrack, Kristina S. Burrack, Marc K. Jenkins, Anne E. Frosch, Anne E. Frosch   +5 more
doaj   +1 more source

Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

The memory CD8+ T cell pool contains phenotypically and transcriptionally heterogeneous subsets with specialized functions and recirculation patterns.
Fonseca, R, Buquicchio, FA, Howitt, MR, Yan, PK, Satpathy, AT, Qi, Y, Belk, JA, Lareau, CA, Wang, F, Obers, A, Tierney, FM, Mackay, LK, Zareie, P, Daniel, B, Yost, KE, Evrard, M, Raposo, CJ, Nico, KF, Gutierrez, JC, Yin, Y   +19 more
core   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Distinct tissue niches contribute to prostate tissue-resident memory T cell differentiation and heterogeneity 2256438

Introduction The prostate is an exocrine organ, a barrier tissue to the male reproductive system, and a site of malignancy, yet prostate tissue-resident memory T cells and the unique cues in the tissue environment remain unexplored.
Amir Ferry, Kianoosh Mempel, Jack Johanneson, Kitty Cheung, Stephanie Anover-Sombke, Natalie Zane, Julien Ishibashi, Baxter Melisso, Sara Quon, Ananda Goldrath, Ethan Xu, Nina Estep, Peter Challita, Maximilian Heeg, Miguel Reina-Campos, Giovanni Galletti, Nicole Scharping, Rana McKay, Kennidy Takehara, Vida Luna, Violante Olivari, Alexander Monell, Peter Skene   +22 more
core   +1 more source

Tissue Resident T Cells In Human Disease

, 2020
Tissue resident memory T cells are a subset of memory T cells that reside in tissue permanently, without entering circulation. Their strategic location at sites of common pathogen entry or reinfection, provides a critical advantage for controlling ...
Hewavisenti, Rehana Vishvangani
core  

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Advances in Bio‐Integrated Edge Computing Systems for Smart and Connected Health

Advanced Materials, EarlyView.
This review explores advances in bio‐integrated edge computing for healthcare, focusing on co‐designing computing, sensing, and energy strategies to overcome integration and power challenges for optimized, decentralized operation. ABSTRACT Recent advances in bio‐integrated healthcare technologies have enabled continuous, high‐resolution monitoring and ...
Gyuwon Kim, Seungwon Yoo, Tae Woog Kang, Yunuo Huang, Woon‐Hong Yeo   +4 more
wiley   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source