Results 111 to 120 of about 70,024 (278)

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Single cell RNA-sequencing delineates CD8+ tissue resident memory T cells maintaining rejection in liver transplantation

Theranostics
Rationale: Understanding the immune mechanisms associated with liver transplantation (LT), particularly the involvement of tissue-resident memory T cells (TRMs), represents a significant challenge.
Xin-Qiang Li, Shi-Peng Li, Yan Wang, Xin Zhou, Feng Wang, Imran Muhammad, Yurong Luo, Yan-Dong Sun, Dan Liu, Bin Wu, Da-Hong Teng, Jinshan Wang, Kai Zhao, Qi Ling, Jin-Zhen Cai   +14 more
semanticscholar   +1 more source

Flexible Sensors for Robotics Tactile Perception: A Review

Advanced Robotics Research, EarlyView.
Flexible tactile sensing for robotics is reviewed through four interconnected dimensions. Physical mechanisms include piezoresistive, capacitive, piezoelectric, triboelectric, iontronic, and optical sensing. Structural design includes bioinspired, defect‐based, and MEMS‐based tactile systems.
Yu Song, Ying Chen, Yihao Chen, Xue Feng
wiley   +1 more source

Transcriptional programming of tissue-resident memory CD8+ T cells

Current Opinion in Immunology, 2018
Tissue-resident memory CD8+ T cells (TRM) are localized in non-lymphoid tissues throughout the body where they mediate long-lived protective immunity at common sites of pathogen exposure. As the signals controlling TRM differentiation are uncovered, it is becoming apparent that the dynamic activities of numerous transcription factors are intricately ...
Milner, J Justin, Goldrath, Ananda W
openaire   +5 more sources

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

CD8+ tissue-resident memory T cells are expanded in primary Sjögren’s disease and can be therapeutically targeted by CD103 blockade

Annals of the Rheumatic Diseases
Objective Tissue-resident memory cells (Trm) are a subset of T cells residing persistently and long-term within specific tissues that contribute to persistent inflammation and tissue damage. We characterised the phenotype and function of Trm and the role
D. Mauro, Xiang Lin, E. Pontarini, Pascale Wehr, G. Guggino, Yuan Tang, Chong Deng, S. Gandolfo, F. Xiao, K. Rui, Enyu Huang, Jie Tian, S. Raimondo, M. Rischmueller, Jane Boroky, S. Downie-Doyle, H. Nel, Adriana Baz-Morelli, A. Hsu, E. Maraskovsky, A. Barr, P. Hemon, L. Chatzis, C. Boschetti, G. Colella, R. Alessandro, A. Rizzo, Jacques-Olivier Pers, M. Bombardieri, R. Thomas, Li-Wei Lu, F. Ciccia   +31 more
semanticscholar   +1 more source

Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer

Journal of Experimental Medicine, 2019
Clarke et al. interrogate human TRM cells from cancer and nonmalignant tissue. These analyses highlight that PD-1 expression in tumor-infiltrating TRM cells was positively correlated with features suggestive of active proliferation and superior ...
J. Clarke, B. Panwar, A. Madrigal, Divya Singh, Ravindra Gujar, O. Wood, Serena J. Chee, S. Eschweiler, E. King, Amiera Awad, Christopher J Hanley, Katy J. McCann, Sourya Bhattacharyya, E. Woo, A. Alzetani, G. Seumois, G. Thomas, A. Ganesan, P. Friedmann, T. Sanchez-Elsner, F. Ay, C. Ottensmeier, P. Vijayanand   +22 more
semanticscholar   +1 more source

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Regulation of T cell tissue residency and activation in human PCLS

Respiratory Research
Background Resident immune cells are central in shaping the lung’s tissue-specific immunity. Precision-cut lung slices (PCLS) preserve the native tissue microenvironment and are therefore an excellent ex vivo model to analyze residency and functionality ...
Tonia Bargmann, Charline Sommer, Lena Stowasser, Sophie Jacob, Louisa Jürgen, Sebastian Konzok, Christopher Werlein, Patrick Zardo, Lavinia Neubert, Danny Jonigk, Hans-Gerd Fieguth, Franziska Dahlmann, Katherina Sewald, Susann Dehmel, Armin Braun   +14 more
doaj   +1 more source

Location versus ID: what matters to lung-resident memory T cells?

Frontiers in Immunology
Tissue-resident memory T cells (TRM cells) are vital for the promotion of barrier immunity. The lung, a tissue constantly exposed to foreign pathogenic or non-pathogenic antigens, is not devoid of these cells.
Bruna Gois Macedo, Mia Y. Masuda, Henrique Borges da Silva   +2 more
doaj   +1 more source