Results 51 to 60 of about 2,307,414 (336)

Harnessing in vitro technologies for conservation of Paeonia emodi, a threatened medicinal and ornamental species

Discover Plants
Paeonia emodi Wall. ex Royle, a valuable medicinal and ornamental species native to the north-western Himalayas, is threatened by overharvesting and habitat loss [1, 2].
Munisa Manzoor, Nidha Zahoor Shahri, Irshad Ahmad Bhat, Zahoor A Kaloo   +3 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Elevational adaptation and phenotypic plasticity of Codonopsis clematidea in the trans-Himalaya

Discover Plants
The process of adapting to changing environmental conditions plays a pivotal role in driving plant diversification. Elevational gradients provide a unique opportunity to investigate adaptation to diverse climatic conditions.
Zarina Khatoon, Seema Singh, Kanize Fatima, Mohd Ibrahim, Sajjad Ali, Sharada Mallubhotla   +5 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Uncovering mercury accumulation and the potential for bacterial bioremediation in response to contamination in the Singalila National Park

Scientific Reports
Several recent investigations into montane regions have reported on excess mercury accumulation in high-altitude forest ecosystems. This study explored the Singalila National Park, located on the Singalila ridge of the Eastern Himalayas, revealing ...
Sukanya Acharyya, Soumya Majumder, Sudeshna Nandi, Arindam Ghosh, Sumedha Saha, Malay Bhattacharya   +5 more
doaj   +1 more source

Synthetic seeds for in vitro preservation of Asparagus officinalis L.

Bulletin of the National Research Centre, 2023
Background Asparagus (Asparagus officinalis) is a perennial vegetable of economic importance for its high nutritional and medicinal value. Male plants are more desirable because of their higher spear yield.
Amira Rashid Sallam, Ghada Abd El-Moneim Hegazi, Shawky Abd El-Hameed Bekheet   +2 more
doaj   +1 more source

Maintenance of head and neck tumor on-chip: gateway to personalized treatment? [PDF]

, 2017
Aim: Head and neck squamous cell carcinomas (HNSCC) are solid tumors with low overall survival (40–60%). In a move toward personalized medicine, maintenance of tumor biopsies in microfluidic tissue culture devices is being developed. Methodology/ results:
Bower, Ruth, Crank, Stephen T, Green, Victoria L., Greenman, John, Karsai, Laszlo, Kuvshinov, Dmitriy, Kuvshinova, Elena, Stafford, Nicholas D   +7 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source