Results 51 to 60 of about 1,285,350 (342)

Towards Physiologic Culture Approaches to Improve Standard Cultivation of Mesenchymal Stem Cells

Cells, 2021
Mesenchymal stem cells (MSCs) are of great interest for their use in cell-based therapies due to their multipotent differentiation and immunomodulatory capacities.
Ilias Nikolits, Sabrina Nebel, Dominik Egger, Sebastian Kreß, Cornelia Kasper   +4 more
doaj   +1 more source

A Functional Human Liver Tissue Model: 3D Bioprinted Co-culture Discoids [PDF]

Biomaterials Advances, Volume 173, 2025, 214288
To reduce costs and delays related to developing new and effective drugs, there is a critical need for improved human liver tissue models. Here we describe an approach for 3D bioprinting functional human liver tissue models, in which we fabricate disc-shaped structures (discoids) 200 {\mu}m in thickness and 1-3 mm in diameter, embedded in a highly ...
arxiv   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Uncovering mercury accumulation and the potential for bacterial bioremediation in response to contamination in the Singalila National Park

Scientific Reports
Several recent investigations into montane regions have reported on excess mercury accumulation in high-altitude forest ecosystems. This study explored the Singalila National Park, located on the Singalila ridge of the Eastern Himalayas, revealing ...
Sukanya Acharyya, Soumya Majumder, Sudeshna Nandi, Arindam Ghosh, Sumedha Saha, Malay Bhattacharya   +5 more
doaj   +1 more source

Study of in vitro antioxidant and antibacterial potential of different tea clones

Pharmacological Research - Modern Chinese Medicine, 2023
Background: Camellia sinensis (L.) O. Kuntze (tea) belongs to the family of Theaceae and is one of the most popular beverages. According to traditional Chinese medicine, its phytochemicals have the ability to cure various diseases of the liver, heart ...
Arindam Ghosh, Soumya Majumder, Ritoja Samadder, Sahadeb Sarkar, Sudeshna Nandi, Preeti Subba, Sourav Chakraborty, Sukanya Acharyya, Sumedha Saha, Malay Bhattacharya   +9 more
doaj  

Dihaploid induction in tetraploid durum wheat (Triticum durum L.) using pollen of Imperata cylindrica

Czech Journal of Genetics and Plant Breeding, 2015
Doubled haploidy breeding protocols have revolutionized the varietal development programmes in bread wheat, however, the protocols have not proved much efficient in durum wheat.
Harinder Kumar CHAUDHARY, Anima MAHATO, Vineeta KAILA, Shoukat Ahmad RATHER, Tisu TAYENG   +4 more
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Production of Triploid Seedless Sweet Orange [Citrus sinensis (L.) Osbeck] cv. Mosambi: A Success Story

Agronomy
The sweet oranges [C. sinensis (L.) Osbeck] produced in India are mainly consumed fresh as a table fruit and in the form of freshly extracted juice. Currently, a fraction of the fruit is processed into products like orange juice, concentrates, pulp, and ...
Vijayakumari Narukulla, Yogesh Lahane, Priya Uge, Shashi Pandey, Krutika Fiske, Kartiki Kawale, Prasanth Tej Kumar Jagannadham, Vasileios Ziogas   +7 more
doaj   +1 more source