Results 71 to 80 of about 6,903,081 (310)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Metabolomic responses of tea [Camellia sinensis (L.) O. Kuntze] leaves to red spider mite [Oligonychus coffeae (Nietner)] and tea mosquito bug [Helopeltis theivora Waterhouse] infestation: a GC–MS-based study

Bulletin of the National Research Centre
Background The tea plant, Camellia sinensis (L.) O. Kuntze, is an evergreen leafy plant whose tender leaves are used in the manufacturing of the world’s second most consumed beverage—tea.
Gopal Sharma, Soumya Majumder, Arindam Ghosh, Malay Bhattacharya   +3 more
doaj   +1 more source

TISSUE CULTURE OF BONE MARROW [PDF]

Annals of the New York Academy of Sciences, 1959
Abstract In cultures of normal human bone marrow in a medium of 20 per cent horse serum and balanced salt solution, estrone stimulated granulopoiesis; testosterone inhibited fibroblast formation markedly and stimulated erythropoiesis; prednisolone inhibited fibroblast formation completely and allowed continued differentiation of all ...
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The potential of prolonged tissue culture to reduce stress generation and retraction in engineered heart valve tissues

, 2013
In tissue-engineered (TE) heart valves, cell-mediated processes cause tissue compaction during culture and leaflet retraction at time of implantation. We have quantified and correlated stress generation, compaction, retraction, and tissue quality during ...
Driessen - Mol, A., Oomens, C.W.J., Baaijens, F.P.T., Vlimmeren, van, M.A.A.   +3 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A miniaturized bioreactor system for the evaluation of cell interaction with designed substrates in perfusion culture [PDF]

, 2011
In tissue engineering, the chemical and topographical cues within three-dimensional (3D) scaffolds are normally tested using static cell cultures but applied directly to tissue cultures in perfusion bioreactors.
M. O. Riehle, J.R. Higginson (7130108), Higginson, J.R., Donoghue, P.S., T. Sun, Nikolaj Gadegaard (1292763), J. R. Higginson, N. Gadegaard, Riehle, M.O., Mathis O. Riehle (1292769), Barnett, S.C., Sun, T., Tao Sun (1255119), Peter S. Donoghue (7128581), S. C. Barnett, Gadegaard, N., P. S. Donoghue, Susan C. Barnett (7128590)   +17 more
core   +1 more source

Arbuscular mycorrhizal technology for the growth enhancement of micropropagated Spilanthes acmella Murr

Plant Protection Science, 2012
Spilanthes acmella (Asteraceae) is an endangered ornamental cum medicinal annual herb. This study reports on the effect of two arbuscular mycorrhizal fungi (Glomus mosseae and Acaulospora laevis) applied either alone or in combination on post ...
Kuldeep YADAV, Narender SINGH, Ashok AGGARWAL   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Sequential use of human-derived medium supplements favours cardiovascular tissue engineering [PDF]

, 2012
For clinical application of tissue engineering strategies, the use of animal-derived serum in culture medium is not recommended, because it can evoke immune responses in patients.
Sluijter, JPG, Kluin, J., Herwerden, van, L.A., Lex A. van Herwerden, Riem Vis, P.W., Bouten, C.V.C., Sluijter, J.P.G., Bouten, CVC Carlijn, Soekhradj - Soechit, R.S., Kluin, Jolanda Jolanda, Joost P. G. Sluijter, Paul W. Riem Vis, van Herwerden, LA Lex, Jolanda Kluin, Bouten, C.V.C.; id_orcid, Soekhradj - Soechit, RS Sarita, R. Sarita Soekhradj-Soechit, Riem Vis, PW, Carlijn V. C. Bouten   +18 more
core   +2 more sources