Results 81 to 90 of about 6,903,081 (310)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Poly-ε-caprolactone scaffold and reduced in vitro cell culture: beneficial effect on compaction and improved valvular tissue formation [PDF]

, 2015
Tissue-engineered heart valves (TEHVs), based on polyglycolic acid (PGA) scaffolds coated with poly-4-hydroxybutyrate (P4HB), have shown promising in vivo results in terms of tissue formation.
Rubbens, M.P., Driessen - Mol, A., Brugmans, M.C.P., Baaijens, F.P.T., Cox, M.A.J.   +4 more
core   +2 more sources

Optimizing immersion time and frequency in a twin-bottle temporary immersion system for mass production of Zingiber officinale Roscoe

Scientific Reports
Ginger (Zingiber officinale Roscoe) is a highly valued medicinal and culinary crop. However, conventional propagation using rhizomes is limited. This study aimed to optimize immersion conditions for the large-scale micropropagation of Z.
Anupan Kongbangkerd, Kanokwan Tubtimsri, Boworn Kunakhonnuruk   +2 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Development of In vitro Slow Growth Culture for Yam (Dioscorea alata L.)

Annals of Tropical Research, 2012
Germplasm collections, the lifeblood of breeding programs, are traditionally maintained in the field. Field genebanks are expensive, subject to genetic erosion, and require several quarantine measures for safe movement of genetic materials.
Villaluz Z. Acedo, Catherine C. Arradaza
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

“Biotechnological approaches for conservation of the vulnerable Capparis spinosa var. aegyptia”

Discover Applied Sciences
Saint Katherine Protectorate, one of the largest protected areas in Egypt, is home to a variety of rare and endangered species. Among them is Capparis spinosa var.
Sabha Salman Mustafa, Heba El-Sayed Ghareb   +1 more
doaj   +1 more source

Influence of different wheat and Imperata cylindrica genetic backgrounds on haploid induction efficiency in wheat doubled haploid breeding

Czech Journal of Genetics and Plant Breeding, 2014
Four Indian and one Japanese accession of Imperata cylindrica were assessed for their influence upon haploid production in F1 generations of 21 wheat crosses (winter × spring, spring × spring and winter × winter) to find an efficient pollen source for ...
Shoukat Ahmad RATHER, Harinder Kumar CHAUDHARY, Vineeta KAILA   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Unfolding phenolics biosynthetic plasticity of Artemisia alba Turra through plant tissue culture techniques

Artemisia alba Turra is an essential oil bearing plant, with Euro-Mediterranean and Southeastern European distribution. One of the distinctive characteristics of its essential oil is the variability of its terpenoid profile due to environmental, genetic ...
Todorova, Milka, Danova, Kalina, Trendafilova, Antoaneta, Wolfram, Evelyn, Peter, Samuel, Ivanova, Viktoria   +5 more
core   +1 more source