Results 91 to 100 of about 1,501,355 (317)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Tissue culture studies of tomato (Lycopersicon esculentum) [PDF]

open access: yes, 2004
Ashwath, N ORCiD: 0000-0002-4032-4507Tomato is a major vegetable crop that has achieved tremendous popularity over the last century. It is grown in almost every country of the world.
Senaratna, T   +7 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Optimizing immersion time and frequency in a twin-bottle temporary immersion system for mass production of Zingiber officinale Roscoe

open access: yesScientific Reports
Ginger (Zingiber officinale Roscoe) is a highly valued medicinal and culinary crop. However, conventional propagation using rhizomes is limited. This study aimed to optimize immersion conditions for the large-scale micropropagation of Z.
Anupan Kongbangkerd   +2 more
doaj   +1 more source

Development of In vitro Slow Growth Culture for Yam (Dioscorea alata L.)

open access: yesAnnals of Tropical Research, 2012
Germplasm collections, the lifeblood of breeding programs, are traditionally maintained in the field. Field genebanks are expensive, subject to genetic erosion, and require several quarantine measures for safe movement of genetic materials.
Villaluz Z. Acedo, Catherine C. Arradaza
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

A comparison of tissue culture response between related tetraploid and dihaploid S. tuberosum genotypes. [PDF]

open access: yes, 1988
The response to tissue culture of a series of related, agronomically useful, dihaploid (2n=2x=24) and tetraploid (2n=4x=48) S. tuberosum genotypes was assessed by regenerating shoots from leaf explants.
Fish, N., Jones, M.G.K., Jones, M. G. K.
core  

Influences of various hormones on the megakaryocyte in bone-marrow tissue culture [PDF]

open access: yes, 1959
In our study on the influences of various hormones and various endocrines on the megakaryocyte function by means of bone-marrow tissue culture, we obtained the following. 1.
Hiraki, Kiyoshi   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Economic Analysis of Tissue-cultured Banana and Sucker-propagated Banana [PDF]

open access: yes
An economic analysis of tissue-cultured banana (TCB) and sucker-propagated banana (SPB) has been presented through studying their costs and returns. The factors influencing the costs of their production have been identified and resource-use efficiency ...
Alagumani, T.
core   +1 more source

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