Results 91 to 100 of about 2,255,345 (306)

Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? [PDF]

open access: yes, 2017
Heart disease is a major cause of morbidity and mortality throughout the world. Some cardiovascular conditions can be modulated by lifestyle factors such as increased exercise or a healthier diet, but many require surgical or pharmacological ...
Agra   +164 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Optimizing immersion time and frequency in a twin-bottle temporary immersion system for mass production of Zingiber officinale Roscoe

open access: yesScientific Reports
Ginger (Zingiber officinale Roscoe) is a highly valued medicinal and culinary crop. However, conventional propagation using rhizomes is limited. This study aimed to optimize immersion conditions for the large-scale micropropagation of Z.
Anupan Kongbangkerd   +2 more
doaj   +1 more source

In Vitro Propagation of Rheophytic Orchid, Epipactis flava Seidenf.—A Comparison of Semi-Solid, Continuous Immersion and Temporary Immersion Systems

open access: yesBiology, 2019
Epipactis flava Seidenf. is an endangered Thai rheophytic orchid that has recently shown a rapid decrease in its natural habitat, prompting an urgent need for conservation using ex situ reintroduction methods.
Boworn Kunakhonnuruk   +2 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

In vitro cloning of Azadirachta indica from root explants

open access: yesBiologia Plantarum, 2011
In vitro cultures of Azadirachta indica A. Juss. were raised by first culturing the root segments on modified Murashige and Skoog (MS) medium supplemented with 8.88 μM 6-benzylaminopurine (BAP), 9.84 μM N6-(2-isopentenyl) adenine (2iP), 5.71 μM indole-3 ...
K. Arora   +4 more
doaj   +1 more source

Validation and clinical application of molecular methods for the identification of molds in tissue [PDF]

open access: yes, 2006
Background. Invasive fungal infections due to less-common molds are an increasing problem, and accurate diagnosis is difficult.Methods. We used our previously established molecular method, which allows species identification of molds in histological ...
Kibbler, CC   +6 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

“Biotechnological approaches for conservation of the vulnerable Capparis spinosa var. aegyptia”

open access: yesDiscover Applied Sciences
Saint Katherine Protectorate, one of the largest protected areas in Egypt, is home to a variety of rare and endangered species. Among them is Capparis spinosa var.
Sabha Salman Mustafa   +1 more
doaj   +1 more source

A retrotransposon-based-strategy for the assessment of genetic and epigenetic stability of oil palm embryogenic suspensions [PDF]

open access: yes, 2012
Clonal regenerants of oil palm (Elaeis guineensis Jacq) can display a detrimental variant phenotype called mantled which affects the floral morphology of adult palms thus lowering oil yields in clonal offspring.
Beulé, Thierry   +7 more
core  

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