Results 91 to 100 of about 1,547,111 (374)

A two-fluid model for tissue growth within\ud a dynamic flow environment [PDF]

, 2008
We study the growth of a tissue construct in a perfusion bioreactor, focussing on its response to the mechanical environment. The bioreactor system is modelled as a two-dimensional channel containing a tissue construct through which a flow of culture ...
Byrne, H. M., O'Dea, R. D., Waters, S. L.   +2 more
core  

Analysis of radiation-induced cell death in head and neck squamous cell carcinoma and rat liver maintained in microfluidic devices [PDF]

, 2013
Objective The aim of this study was to investigate how head and neck squamous cell carcinoma (HNSCC) tissue biopsies maintained in a pseudo in vivo environment within a bespoke microfluidic device respond to radiation treatment.
Burcombe R, Cai L, Eriksson D, Eriksson D, Fernberg JO, Hattersley SM, Hattersley SM, Ianzini F, Jemal A, Kamotani Y, Kroemer G, Lee P, Ma H, Mamouni J, Mansilla S, Mauk MG, Mirzaie-Joniani H, Mulhall HJ, Nevill JT, Parkin DM, Reddy AC, Remmerbach TW, Skoda C, Ts’ao C, Weigum SE, Withrow KP, Young EW, Ziober BL   +27 more
core   +2 more sources

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Plant Breeding Techniques in Tissue Culture to Improve the Quality of Orchids

Jurnal Ilmu Pertanian Indonesia
Conventional orchid cultivation is thought to be ineffective and time-consuming. Simple tissue culture procedures are insufficient to increase orchid quality. The need for ongoing development can be met by integrating different plant breeding strategies
Mukhamad Su'udi, Waki’atil Rosida, El Shania Ravitamala, Arif Mohammad Siddiq, Rendy Setiawan, Dwi Setyati, Asyifa Yasmin Ningrum, Wasiatur Roziqoh   +7 more
doaj   +1 more source

Hydrogen peroxide in micropropagation of Lilium: A comparison with a traditional methodology [PDF]

, 2006
The micropropagation of Lilium longiflorum requires adequate equipment which may not be afforded by small laboratories or producers. In this work we compared traditional methodology with a protocol that included easily available elements to sterilize ...
Curvetto, Nestor Raul, Marinangeli, Pablo Alejandro, Mockel, Gabriela Carolina   +2 more
core  

Angiogenesis in tissue engineering : Breathing life into constructed tissue substitutes [PDF]

, 2006
Long-term function of three-dimensional (3D) tissue constructs depends on adequate vascularization after implantation. Accordingly, research in tissue engineering has focused on the analysis of angiogenesis.
Amon, Michaela, Carvalho, Carlos, Farhadi, Jian, Germann, Gunter, Haeufel, Joerg M., Harder, Yves, Heberer, Michael, Junker, Dominic, Laschke, Matthias W., Martin, Ivan, Menger, Michael D., Ring, Andrej, Ruecker, Martin, Schramm, Rene, Torio-Padron, Nestor, Vollmar, Brigitte   +15 more
core   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

RNA interference in marine and freshwater sponges [PDF]

, 2011
Background: The marine sponge Tethya wilhelma and the freshwater sponge Ephydatia muelleri are emerging model organisms to study evolution, gene regulation, development, and physiology in non-bilaterian animal systems. Thus far, functional methods (i.e.,
Cieniewicz, Brandon, Danka, Elizabeth S., Haen, Karri M., Hammel, Jörg U., Hill, April L., Hill, Malcolm S., Knight, Scott W., Lavrov, Dennis V., Nickel, Michael, Posfai, Dora, Rivera, Ajna S., Winters, Ian P., Wörheide, Gert   +12 more
core   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source