Results 91 to 100 of about 413,256 (382)

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Opinion of medical students compared with non-medical students about organ donation and its bioethical conflicts

Journal of Education, Health and Sport, 2021
Introduction and Purpose: Organ donation is controversial. Chilean legislation failed to increase donors. However, it seems that there is an enthusiasm to be an organ donor, so education is important. Therefore, medical students play an important role in
Esteban Muñoz-Niklitschek, Paulo Morales-Delgado, Emilio Muñoz-Oyarzo, Rogelio Parra-Venegas   +3 more
doaj   +1 more source

Donors Retain No Rights to Donated Tissue

AMA Journal of Ethics, 2009
Ownership rights to tissue donated for research end when the tissue leaves the body, as does all claim to benefit from commercial cell lines or other products derived from the tissue. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +3 more sources

Tensin1 expression and function in chronic obstructive pulmonary disease [PDF]

, 2019
open access articleChronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in ...
Amrani, Y., Bradding, Peter, Brightling, C. E., Clark, K., Gooptu, B., Roach, K.M., Smallwood, Dawn T., Stylianou, P.   +7 more
core   +1 more source

Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. [PDF]

, 2020
The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood.
Cavrois, Marielle, Deeks, Steven G, Frouard, Julie, Gramatica, Andrea, Greene, Warner C, Hoh, Rebecca, Hsiao, Feng, Jones, R Brad, Lee, Guinevere Q, Lee, Sulggi, Luo, Xiaoyu, Roan, Nadia R, Roychoudhury, Pavitra, Schwarzer, Roland, Telwatte, Sushama, Xie, Guorui, Yukl, Steven A   +16 more
core   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Ultra-Fast Fluorescence Imaging in Vivo with Conjugated Polymer Fluorophores in the Second Near-Infrared Window [PDF]

, 2014
In vivo fluorescence imaging in the second near-infrared window (1.0-1.7 microns) can afford deep tissue penetration and high spatial resolution, owing to the reduced scattering of long-wavelength photons. Here, we synthesize a series of low-bandgap donor/acceptor copolymers with tunable emission wavelengths of 1050-1350 nm in this window. Non-covalent
arxiv   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

The rejection that defies anti-rejection drugs. Chronic vascular rejection (allograft vasculopathy): The role of terminology and linguistic relativity [PDF]

arXiv, 2023
Solid organ transplantation has by now become a common medical procedure. Owing to the introduction of new immunosuppressive drugs, the allograft loss due to acute rejection has been reduced significantly over time. Tragically, the number of donor organs lost due to allograft vasculopathy (AV), generally named chronic vascular rejection or chronic ...
arxiv  

Commercialisation of the supply of organs for transplantation [PDF]

, 2001
Internationally, there is a shortage of organs available for organ donation. Human tissue and cells are becoming increasingly valuable as part of commercially valuable biotechnological research.
Thomas, Cordelia
core