Results 121 to 130 of about 6,889,134 (415)

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Bridging high resolution sub-cellular imaging with physiologically relevant engineered tissues [PDF]

While high-resolution microscopic techniques are crucial for studying cellular structures in cell biology, obtaining such images from thick 3D engineered tissues remains challenging. In this review, we explore advancements in fluorescence microscopy, alongside the use of various fluorescent probes and material processing techniques to address these ...
arxiv   +1 more source

A new theory of fluid-solid coupling in a porous medium for application to the ultrasonic evaluation of tissue remodeling using bioelastomers [PDF]

arXiv, 2020
Bioelastomers have demonstrated tremendous value and potential in the field of tissue repair due to increasing health demands. Improved non-invasive methods are required for monitoring tissue development assisted by bioelastomers. In this paper, we present a novel theory of fluid-solid coupling in a porous medium for application to the ultrasonic ...
arxiv  

3D and 4D Printing of Polymers for Tissue Engineering Applications

Frontiers in Bioengineering and Biotechnology, 2019
Three-dimensional (3D) and Four-dimensional (4D) printing emerged as the next generation of fabrication techniques, spanning across various research areas, such as engineering, chemistry, biology, computer science, and materials science.
Dilara Goksu Tamay, Tugba Dursun Usal, Ayse Selcen Alagoz, D. Yucel, N. Hasırcı, V. Hasırcı   +5 more
semanticscholar   +1 more source

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Modelling the effect of curvature on the collective behaviour of cells growing new tissue [PDF]

arXiv, 2016
The growth of several biological tissues is known to be controlled in part by local geometrical features, such as the curvature of the tissue interface. This control leads to changes in tissue shape that in turn can affect the tissue's evolution. Understanding the cellular basis of this control is highly significant for bioscaffold tissue engineering ...
arxiv  

Accuracy and Mechanical Properties of Open-Cell Microstructures Fabricated by Selective Laser Sintering [PDF]

, 2007
This paper investigates the applicability of selective laser sintering (SLS) for the manufacture of scaffold geometries for bone tissue engineering applications.
Eosoly, S., Looney, L., Ryder, G., Tansey, T.   +3 more
core   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Chapter 9 TISSUE ENGINEERING [PDF]

arXiv, 2015
Tissue Engineering (TE) is an interdisciplinary field dealing with the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ. Currently, TE is emerging as an invaluable field of study and is one of the most promising fields for the next century ...
arxiv