Results 101 to 110 of about 6,837,049 (299)

Tissue engineering: part 2 [Frontiers of biomedical engineering]

, 2014
Educação Superior::Engenharias::Engenharia BiomédicaPresents a course about the basic concepts of biomedical engineering with the Professor of Chemical and Biomedical Engineering at Yale University, W. Mark Saltzman.
Saltzman, W. Mark
core  

Characterization of scaffolds for neural tissue engineering

, 2023
With the advancement of tissue engineering techniques, the repair of nerve injuries has acquired a novel dimension. It is now appropriate to establish a scaffold that entirely mimics the biological and mechanical properties of real human tissue using ...
CESUR, SÜMEYYE, ULAĞ, SONGÜL
core  

Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration

Nature Communications
Chronic diabetic wounds present a critical clinical challenge due to persistent inflammation and compromised healing. Here, we report a sprayable nanozyme hydrogel that epigenetically remodels macrophages (Mφ) to suppress inflammation and coordinate ...
Amal George Kurian, Jeong-Hui Park, Shanika Karunasagara, Archita Gupta, Shreyas Kumar Jain, Tanza Baby, Ueon Sang Shin, Sak Lee, Buuvee Bayarkhangai, Rajendra K. Singh, Jung-Hwan Lee, Kam W. Leong, Hae-Won Kim   +12 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Tissue engineering: part 2 [Frontiers of biomedical engineering]

, 2008
Educação Superior::Engenharias::Engenharia BiomédicaPresents a course about the basic concepts of biomedical engineering with the Professor of Chemical and Biomedical Engineering at Yale University, W. Mark Saltzman.
Saltzman, W. Mark
core  

Substrates for cardiovascular tissue engineering

, 2011
Cardiovascular tissue engineering aims to find solutions for the suboptimal regeneration of heart valves, arteries and myocardium by creating ‘living’ tissue replacements outside (in vitro) or inside (in situ) the human body.
Baaijens, FPT Frank, Pedron, S, Driessen - Mol, A., Bouten, C.V.C., S. Pedron, Dankers, PYW Patricia, Bouten, CVC Carlijn, Pedron, S., A. Driessen-Mol, F.P.T. Baaijens, Baaijens, F.P.T., A.M.A. Brizard, Brizard, Aurelie M A, Dankers, P.Y.W., C.V.C. Bouten, Driessen-Mol, A Anita, Bouten, C.V.C.; id_orcid, Brizard, A.M., P.Y.W. Dankers   +18 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Tissue engineering scaffold material of porous nanohydroxyapatite/polyamide 66

International Journal of Nanomedicine, 2010
Qian Xu1, Hongyan Lu1, Jingchao Zhang1, Guoyu Lu2, Zhennan Deng2, Anchun Mo31State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, P.R. China; 2Research Center for Nano-Biomaterials, Sichuan University, Chengdu, 610064, P.R.
Qian Xu, Hongyan Lu, Jingchao Zhang, et al   +3 more
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