Results 121 to 130 of about 713,698 (308)
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Development of methods for the tissue engineering of cardiac valves using mesenchymal stem cells [PDF]
, 2004 Cardiac valve replacement is the second most common heart operation in the Western World. Valve replacements currently available are poorly adapted for use in young patients who typically require multiple re-operations as they grow, resulting in ...
Knight, Richard Lewis
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Preparation and Evaluation of PLGA-Silica Scaffold with Human Adipose-Derived Stromal Cells for Bone Tissue Engineering [PDF]
, 2019 One of the main goals of bone tissue engineering is to develop suitable bio-acceptable materials for bone graft substitutes, especially for filling large defects In the present study, porous poly(lactic-co-glycolic acid) (PLGA)-silica scaffolds were ...
Lee, SH +10 more
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Carbon based materials in conducting tissue engineering
Materials Research ExpressConducting materials based on carbon have been widely investigated in conducting tissue engineering applications due to their outstanding physical, chemical, thermal, and electric properties in recent years. Carbon based conductive materials can generate
Elif Sancar +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A stable matrix for generation of tissue-engineered nonthrombogenic vascular grafts [PDF]
, 2002 The potential of freeze-dried fibrin glue (FG) in combination with growth factor (GF) and gelatin (GEL) is evaluated for use as a matrix for endothelialization of artificial vascular grafts made of polytetrafluoroethylene (PTFE, Teflon) and ...
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Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Tissue engineering of a tracheal substitute [PDF]
, 2004 Lectin histochemistry and scanning electron microscopy (SEM) was used to assess the growth and characterise the differentiation of human respiratory epithelial cells (REC) cultured on two biomaterial scaffolds.
Ziegelaar, Brian
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