Results 111 to 120 of about 7,368,901 (300)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Cell-based bone tissue engineering. [PDF]

PLoS Medicine, 2007
Gert J Meijer, Joost D de Bruijn, Ron Koole, Clemens A van Blitterswijk   +3 more
doaj   +1 more source

Short-term stress preconditioning activates sympathetic innervation in the testes to mitigate testicular ischemia-reperfusion injury

Journal of Neuroinflammation
Testicular tissues are highly vulnerable to oxidative stress and external insults due to their unique physiological microenvironment; thus, developing protective interventions is critical.
Liyong Liu, Ruiming Xu, Heshe Li, Yuanchen Ma, Yue Shu, Hongjie Liang, Tao Wang, Jiang Hao, Weiqiang Li, Andy Peng Xiang, Mei Hua Jiang, Weijun Huang   +11 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Carbon based materials in conducting tissue engineering

Materials Research Express
Conducting materials based on carbon have been widely investigated in conducting tissue engineering applications due to their outstanding physical, chemical, thermal, and electric properties in recent years. Carbon based conductive materials can generate
Elif Sancar, Büşra Oktay, Esma Ahlatcıoğlu Özerol   +2 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Tissue Engineering for Cardiac Regeneration

, 2011
Tissue engineering is an interdisciplinary field that involves engineering, chemistry, biology and medicine and is emerging in the last decade as a possible approach to regenerate an injured organ by using cells, matrix, biological active molecules and ...
Gaetani R., Doevendans P. A. F., Messina E., Sluijter J. P. G., Elisa Messina, Pieter A. F. Doevendans, Roberto Gaetani, Joost P. G. Sluijter   +7 more
core   +1 more source

Non-alcoholic beverages, unknown influence on cell proliferation – an [i]in vitro[/i] study

Annals of Agricultural and Environmental Medicine, 2014
Introduction and objective. The aim of the presented study was to check differences between ‘Diet’ and ‘non-Diet’ soft drinks on cell proliferation. Materials and methods.
Maciej Nowacki, Jan Adamowicz, Joanna Olkowska, Katarzyna Pietkun, Tomasz Kloskowski, Anna Bajek, Tomasz Drewa   +6 more
doaj