Results 91 to 100 of about 7,368,901 (300)

In vivo cartilage tissue engineering

Journal of Orthopaedic Surgery and Research, 2018
Background Biologic treatment options for cartilage injuries require chondrocyte expansion using cell culture. Clinical application is accomplished in two surgical sessions and is expensive. If isolation of chondrocytes and stimulus for proliferation and
B. Gurer, S. Cabuk, O. Karakus, N. Yilmaz, C. Yilmaz   +4 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling. [PDF]

FEBS Open Bio
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Porritt H, Winbo A, Malmström J.
europepmc   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Ocular Tissue Engineering

, 2016
Tissue engineering emerged back in the 1990s as a new concept to overcome the problem of tissue and organ failure. Over recent decades, there has been incredible progress towards the regeneration of tissues such as bone, heart valves, cartilage, cornea ...

core  

Bio-inspired design of a magnetically active trilayered scaffold for cartilage tissue engineering [PDF]

, 2015
An important topic in cartilage tissue engineering is the development of biomimetic scaffolds which mimic the depth/dependent material properties of the native tissue.
Brady, MA, Ethier, CR, Talvard, L, Vella, A   +3 more
core   +1 more source

Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration

Journal of Nanobiotechnology
Treating chronic bone injuries and defects remains a significant challenge in orthopedic medicine, impacting patient mobility, recovery time, and healthcare costs.
Archita Gupta, Kyung Wook Kim, Amal George Kurian, Shreyas Kumar Jain, Suparna Bhattacharya, Rajendra K. Singh, Hae-Won Kim   +6 more
doaj   +1 more source

Tissue Engineering of Corneal Endothelium

Journal of Functional Biomaterials, 2012
Human corneal endothelial cells (HCECs) do not replicate after wounding. Therefore, corneal endothelial deficiency can result in irreversible corneal edema. Descemet stripping automated endothelial keratoplasty (DSAEK) allows selective replacement of the
Satoru Yamagami, Tatsuya Mimura, Seiichi Yokoo   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Principles of tissue engineering /

, 2007
First published in 1997, Principles of Tissue Engineering is the widely recognized definitive resource in the field. The third edition provides a much needed update of the rapid progress that has been achieved in the field, combining the prerequisites ...
Vacanti, Joseph., Langer, Robert S., Lanza, R. P.(Robert Paul),   +2 more
core  

Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration

Nature Communications
Chronic diabetic wounds present a critical clinical challenge due to persistent inflammation and compromised healing. Here, we report a sprayable nanozyme hydrogel that epigenetically remodels macrophages (Mφ) to suppress inflammation and coordinate ...
Amal George Kurian, Jeong-Hui Park, Shanika Karunasagara, Archita Gupta, Shreyas Kumar Jain, Tanza Baby, Ueon Sang Shin, Sak Lee, Buuvee Bayarkhangai, Rajendra K. Singh, Jung-Hwan Lee, Kam W. Leong, Hae-Won Kim   +12 more
doaj   +1 more source