Results 91 to 100 of about 713,698 (308)

Biomechanics and mechanobiology in functional tissue engineering [PDF]

, 2014
The field of tissue engineering continues to expand and mature, and several products are now in clinical use, with numerous other preclinical and clinical studies underway.
Baaijens, FPT Frank, Guilak, F, Butler, D.L., Butler, DL, Guilak, F., Baaijens, F.P.T., Goldstein, S.A., Goldstein, SA   +7 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

In vivo cartilage tissue engineering

Journal of Orthopaedic Surgery and Research, 2018
Background Biologic treatment options for cartilage injuries require chondrocyte expansion using cell culture. Clinical application is accomplished in two surgical sessions and is expensive. If isolation of chondrocytes and stimulus for proliferation and
B. Gurer, S. Cabuk, O. Karakus, N. Yilmaz, C. Yilmaz   +4 more
doaj   +1 more source

Tissue Engineering for Jawbone

Nihon Hotetsu Shika Gakkai Zasshi, 2005
One goal of jawbone reconstruction is to regenerate bone that is strong enough to support dentures or dental implants. Here we describe mandibular reconstructions using bioabsorbable poly (L-lactic acid) (PLLA) mesh and particulate cancellous bone and marrow (PCBM).
openaire   +3 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Tissue engineering [PDF]

, 2001
Tissue Engineering is an emerging discipline that aims at the development ofbioartificial substitutesfor the repair or replacement of damaged tissues and organs.
Peters, G.W.M., Bouten, C.V.C., Bouten, C.V.C.; id_orcid, Rutten, M.C.M., Oomens, C.W.J., Baaijens, F.P.T.   +5 more
core  

Tissue Engineering of Corneal Endothelium

Journal of Functional Biomaterials, 2012
Human corneal endothelial cells (HCECs) do not replicate after wounding. Therefore, corneal endothelial deficiency can result in irreversible corneal edema. Descemet stripping automated endothelial keratoplasty (DSAEK) allows selective replacement of the
Satoru Yamagami, Tatsuya Mimura, Seiichi Yokoo   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

New ways for tissue engineering in dentistry [PDF]

, 2017
The objective of this paper is to provide an insight of the different materials and techniques that can be used in engineering oral tissues and their potential employment in dentistry. An overview of the traditional methods of recovering lost oral tissue
Khaffaf, Havrest
core  

Liquid-crystalline nanoarchitectures for tissue engineering

Beilstein Journal of Nanotechnology, 2018
Hierarchical orders are found throughout all levels of biosystems, from simple biopolymers, subcellular organelles, single cells, and macroscopic tissues to bulky organs.
Baeckkyoung Sung, Min-Ho Kim
doaj   +1 more source