Results 81 to 90 of about 7,368,901 (300)

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Tissue Engineering

BioTechniques, 2007
Lynne Lederman
doaj   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A novel bioreactor for ligament tissue engineering

, 2008
Bioreactors are defined as devices in which biological and/or biochemical processes develop under closely monitored and tightly controlled environmental and operating conditions (e.g.
Wang, Xiong, Kahn, Cyril J.F., Vaquette, Cédryck, Rahouadj, Rachid   +3 more
core   +1 more source

In vitro characterization of immune-related properties of human fetal bone cells for potential tissue engineering applications [PDF]

, 2009
We describe herein some immunological properties of human fetal bone cells recently tested for bone tissue-engineering applications. Adult mesenchymal stem cells (MSCs) and osteoblasts were included in the study for comparison.
Martin, I, Arnaud Scherberich, Montjovent, MO, Scherberich, A, Scherberich, Arnaud, Lee Ann Applegate, Montjovent, Marc-Olivier, Marc-Olivier Montjovent, Scaletta, Corinne, Dominique P. Pioletti, Bocelli-Tyndall, Chiara, Martin, Ivan, Applegate, LA, Laurent-Applegate, Lee, Bocelli-Tyndall, C., Pioletti, DP, Scherberich, A., Silke Mark, Montjovent, M.O., Scaletta, C, Pioletti, Dominique P., Mark, Silke, Mark, S., Bocelli-Tyndall, C, Applegate, Lee Ann, Mark, S, Pioletti, D.P., Corinne Scaletta, Scaletta, C., Ivan Martin, Martin, I., Applegate, L.A., Chiara Bocelli-Tyndall, Applegate LA, Pioletti DP, Mark S, Martin I, Bocelli-Tyndall C, Montjovent MO, Scaletta C, Scherberich A, Montjovent, Marc-Oliver   +41 more
core   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Extreme Tissue Engineering Concepts and Strategies for Tissue Fabrication

, 2013
Robert A. Brown is Professor of Tissue Engineering and Director of the Centre for Tissue Regeneration Science at University College London, UK. He is also co-ordinator of the London Tissue Engineering Consortium (Tissue Bioreactor Science) and the ...
Brown, Robert A.
core  

Use of poly vinyl alcohol (PVA) cryogelation for tissue engineering: composites, scaffold formation and cell encapsulation [PDF]

, 2009
PVA cryogelation is a physical hydrogel formation method, which yields cryogels with comparable mechanical properties to vascular tissue. However PVA cryogels are not suitable for cell attachment and proliferation alone.
Vrana, Nihal Engin
core   +1 more source

Nerve Tissue Engineering

, 2011
In this chapter, we aim at providing an up-to-date review on nerve tissue engineering, focusing on both the peripheral and the central nervous systems (PNS and CNS, respectively).
MADAGHIELE, Marta, M. Carrozzo, Ambrosio L., M. Madaghiele, L. Salvatore, SANNINO, Alessandro, SALVATORE, LUCA, CARROZZO, MARINA, L. Ambrosio, A. Sannino   +9 more
core   +1 more source