Results 71 to 80 of about 1,261,489 (334)

Engineered cardiac tissues [PDF]

Current Opinion in Biotechnology, 2011
Cardiac tissue engineering offers the promise of creating functional tissue replacements for use in the failing heart or for in vitro drug screening. The last decade has seen a great deal of progress in this field with new advances in interdisciplinary areas such as developmental biology, genetic engineering, biomaterials, polymer science, bioreactor ...
Rohin K, Iyer, Loraine L Y, Chiu, Lewis A, Reis, Milica, Radisic   +3 more
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Nanomaterials for Cardiac Tissue Engineering

Molecules, 2020
End stage heart failure is a major cause of death in the US. At present, organ transplant and left-ventricular assist devices remain the only viable treatments for these patients.
Devang R. Amin, Eric Sink, Suguna P. Narayan, Mostafa Abdel-Hafiz, Luisa Mestroni, Brisa Peña   +5 more
doaj   +1 more source

SCAFFOLDS FOR TISSUE ENGINEERING – INTRODUCTION [PDF]

Acta Tecnología, 2018
For the past 40 years we have developed a variety of techniques to create scaffolds. Raw materials, mostly polymers, are processed and shaped into different structures depending on various applications in tissue engineering.
Radovan Hudák, Marianna Trebuňová, Jozef Živčák, Daniel Kottfer   +3 more
doaj   +1 more source

Polymer- and Hybrid-Based Biomaterials for Interstitial, Connective, Vascular, Nerve, Visceral and Musculoskeletal Tissue Engineering [PDF]

, 2020
In this review, materials based on polymers and hybrids possessing both organic and inorganic contents for repairing or facilitating cell growth in tissue engineering are discussed.
Abalymov, Anatolii, Parakhonskiy, Bogdan, Skirtach, Andre   +2 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

ITRAQ-based quantitative proteomic analysis of Cynops orientalis limb regeneration

BMC Genomics, 2017
Background Salamanders regenerate their limbs after amputation. However, the molecular mechanism of this unique regeneration remains unclear. In this study, isobaric tags for relative and absolute quantification (iTRAQ) coupled with liquid chromatography
Jie Tang, Yuan Yu, Hanxue Zheng, Lu Yin, Mei Sun, Wenjun Wang, Jihong Cui, Wenguang Liu, Xin Xie, Fulin Chen   +9 more
doaj   +1 more source

Development of a Computational Model for Cell Activity in a Nano-Scaffold [PDF]

, 2020
Tissue engineering utilizes nano-scaffolds to direct cell growth and control cell behavior. Since cells occupy specific spaces within extracellular matrix (ECM) it’s important to understand how the geometry of these spaces influence cell behaviors such ...
Babcock, Ethan, Luke, Bethany
core   +1 more source

Myocardial tissue engineering [PDF]

British Medical Bulletin, 2008
Regeneration of the infarcted myocardium after a heart attack is one of the most challenging aspects in tissue engineering. Suitable cell sources and optimized biocompatible materials must be identified.In this review, we briefly discuss the current therapeutic options available to patients with heart failure post-myocardial infarction. We describe the
Hedeer, Jawad, Alex R, Lyon, Sian E, Harding, Nadire N, Ali, Aldo R, Boccaccini   +4 more
openaire   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source