Results 91 to 100 of about 418,065 (313)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Semi-preparative isolation of plant sulfoquinovosyldiacylglycerols by solid phase extraction and HPLC procedures.

Journal of Lipid Research, 1996
Techniques are described for the semi-preparative isolation of sulfoquinovosyldiacylglycerol from plant leaf tissue lipid extracts and the resolution and analysis of component molecular species.
H A Norman, C F Mischke, B Allen, J S Vincent   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell-free Embryonic Stem Cell Extract-mediated Derivation of Multi-potent Stem Cells from NIH3T3 Fibroblasts for Functional and Anatomical Ischemic Tissue Repair

, 2007
The oocyte-independent generation of multipotent stem cells is one of the goals in regenerative medicine. We report that upon exposure to mouse ES cell (ESC) extracts, reversibly permeabilized NIH3T3 cells undergo de-differentiation followed by stimulus ...
Erin Lambers, Johnson Rajasingh, Hiromichi Hamada, Deepali Ahluwalia, Tina Thorne, Ilona Goukassian, Kenneth M. Rosen, Yan Zhu, Douglas W. Losordo, Evelyn Bord, Prasanna Krishnamurthy, Gangjian Qin, Karen Schlauch, Raj Kishore   +13 more
core  

Characterizing cytotoxic and estrogenic activity of Arctic char tissue extracts in primary Arctic char hepatocytes [PDF]

, 2017
Contaminants from various anthropogenic activities are detected in the Arctic due to long-range atmospheric transport, ocean currents, and living organisms such as migrating fish or seabirds.
Hultman, Maria Thérése, Tollefsen, Knut Erik, Petersen, Karina, Karina Petersen, Jenny Bytingsvik, Harju, Mikael, Knut Erik Tollefsen, Bytingsvik, Jenny, Maria T. Hultman, Mikael Harju, Evenset, Anita, Anita Evenset   +11 more
core   +1 more source

Absence of lipemia clearing factor lipase in human adipose tissue*

Journal of Lipid Research, 1961
Clearing factor lipase activity was present in abundance in chicken adipose tissue extracts. No such activity was demonstrable in seven of nine samples of human adipose tissue removed at surgery.
H. Engelberg
doaj   +1 more source

Antibacterial potential of Luidia clathrata (sea star) tissue extracts against selected pathogenic bacteria. [PDF]

PLoS One, 2023
Parajuli K, Fahim N, Mumu S, Palu R, Mustafa A.   +4 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Results from linearity assessment of cortisol enzyme immunoassay (EIA) with blubber tissue extracts.

, 2015
Serial dilutions of extracts (open circles) show parallelism with the standards of the cortisol EIA (dark squares) (observed/expected = 1.01, 95%CI: 99.3–1.06); an indication that the assay is measuring the same antigens in the blubber as in the ...
Camryn D. Allen (688383), Susan J. Chivers (688384), Kerri Danil (439650), Michelle N. Robbins (688382), Marisa L. Trego (439648), Nicholas M. Kellar (439649), Krista N. Catelani (688381)   +6 more
core   +1 more source

An investigation into the toxicity of tissue extracts from two distinct marine Polychaeta. [PDF]

Toxicon X, 2022
D'Ambrosio M, Ramos Í, Martins C, Costa PM.   +3 more
europepmc   +1 more source