Results 121 to 130 of about 418,065 (313)
RNA Contaminates Glycosaminoglycans Extracted from Cells and Tissues.
PLoS ONE, 2016 Glycosaminoglycans (GAGs) are linear negatively charged polysaccharides and important components of extracellular matrices and cell surface glycan layers such as the endothelial glycocalyx.
Jasper J van Gemst +6 more
doaj +1 more source
Auto-Antigenicity of Connective Tissue Extracts.
Experimental Biology and Medicine, 1963 Summary1. Rabbit tendon extracts, reinjected into the donor animals produced circulating complement fixing antibodies, skin reactivity of the delayed type and fixation of antibody to synovia and interstitial spaces of several organs. 2. The growth of the animals was stunted, but no other abnormalities were demonstrable. 3.
P, HELLER, V J, YAKULIS
openaire +2 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Imaging mass spectrometry approaches for the detection and localisation of drug compounds and small molecules in tissue [PDF]
A crucial and challenging aspect of the drug development process is the requirement to measure the distribution of a pharmaceutical compound and its metabolites in tissue.
Blatherwick, Eleanor Q.
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Journal of Oral Biology and Craniofacial ResearchObjective: Proper management of orthodontic treatment in diabetic patients is essential due to the heightened risk of periodontal tissue breakdown associated with hyperglycemia.
Nuzulul Hikmah +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2013 Background aims. Human adipose tissue-derived stem cells (hASCs) can be easily (and inexpensively) expanded in culture, and their high plasticity allows their conversion to different cell types.
Valenzuela, Aurora +5 more
core +1 more source
Bovine fetal tissue extracts as an alternative to fetal serum for in vitro reproduction of viruses
, 2020 The authors assessed the possibility of substitution of the serum component with tissue extracts (muscles, liver, kidneys) of bovine fetuses in the culture medium during the cultivation of transplanted LEK and Vero cell lines, as well as the reproduction
Albert K. Galiullin +3 more
core +1 more source