Results 191 to 200 of about 8,614,068 (306)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Tissue Factor/Factor XIa Dual-activated Thrombin Generation is Able to Reliably Measure Thrombin Generation at All Hemophilia A Disease Severities. [PDF]

TH Open
van de Berg TW, Heinzmann A, Thomassen S, Schols SEM, Heubel-Moenen FCJI, van Es N, Rosendaal FR, Gouw S, Hackeng TM, Beckers EAM.   +9 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Tissue Factor [PDF]

Science-Business eXchange, 2011
  +4 more sources

N-myc and STAT interactor promotes poly(I:C)-induced pulmonary coagulopathy via STAT3-dependent tissue factor. [PDF]

Front Immunol
Zhang J, Zhou Y, Mu Q, Zheng X, Qin J, Liang H.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Evaluation of 3 commercial assays for the measurement of tissue factor activity in human plasma. [PDF]

Res Pract Thromb Haemost
Sachetto ATA, Monroe DM, Mackman N.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Prognostic and histologic significances of the expression profile of membrane tissue factor for aggressive endometrial carcinomas. [PDF]

Oncologist
Fujieda K, Minaguchi T, Ono K, Kuboya T, Suto A, Qi N, Itagaki H, Tenjimbayashi Y, Shikama A, Akiyama A, Nakao S, Kobayashi Y, Satoh T.   +12 more
europepmc   +1 more source

BCTB FFPE Microscope Images

This BCTB subcollection consists of microscope images of FFPE tissue samples, scanned with a Hamamatsu Nanozoomer. Partial low-resolution images are available through the Research Query page on the BCTB website.

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