Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation [PDF]
Redox Biology, 2023 Tissue factor pathway inhibitor (TFPI) is an important regulator of coagulation and a link between inflammation and thrombosis. Here we investigated whether endothelial cell-driven oxidative post-translational modifications could have an impact on TFPI ...
Janina Wittig +8 more
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Mechanism and kinetics study of MG1113, an anti–tissue factor pathway inhibitor antibody promoting hemostasis in hemophilia [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Targeting tissue factor pathway inhibitor (TFPI) is an emerging hemostatic rebalancing strategy for hemophilia. MG1113 is a humanized monoclonal antibody designed to specifically bind the Kunitz domain (KD)2 of TFPI.
Heechun Kwak, Hyun-Ja Nam, Sung Ho Hwang
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Extracellular vesicle tissue factor and tissue factor pathway inhibitor are independent discriminators of sepsis-induced coagulopathy [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Sepsis-induced disseminated intravascular coagulopathy (DIC) remains a challenging clinical entity associated with significant morbidity and mortality.
Anna K. Tobiasch +7 more
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MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endothelium [PDF]
Scientific Reports, 2022 A large portion of the genome is transcribed into non-coding RNA, which does not encode protein. Many long non-coding RNAs (lncRNAs) have been shown to be involved in important regulatory processes such as genomic imprinting and chromatin modification ...
Veerle Kremer +8 more
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Associations of tissue factor and tissue factor pathway inhibitor with organ dysfunctions in septic shock [PDF]
Scientific ReportsCoagulopathy, microvascular alterations and concomitant organ dysfunctions are hallmarks of sepsis. Attempts to attenuate coagulation activation with an inhibitor of tissue factor (TF), i.e.
Georg Franz Lehner +9 more
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Tissue factor pathway inhibitor 2 (TFPI2) is a potential serum biomarker for clear cell renal carcinoma [PDF]
Scientific ReportsRenal and ovarian clear cell carcinoma (CCC) are both characterized by a clear cytoplasm and exhibit similar genomic alterations and clinical characteristics. We hypothesized that both CCCs may share clinical biomarker. Tissue factor pathway inhibitor 2 (
Hiroki Ito +12 more
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Biomedicines, 2023 Background: Preeclampsia is a hypertensive disorder of pregnancy that causes maternal and perinatal morbidity and mortality worldwide. Preeclampsia is associated with complex abnormalities of the coagulation and fibrinolytic system. Tissue factor (TF) is
Hiroshi Kobayashi +4 more
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Tissue factor pathway inhibitor for prediction of placenta-mediated adverse pregnancy outcomes in high-risk women: AngioPred study. [PDF]
PLoS ONE, 2017 OBJECTIVE:The study aimed to evaluate if the rate of tissue factor pathway inhibitor during pregnancy and following delivery could be a predictive factor for placenta-mediated adverse pregnancy outcomes in high-risk women.
Aurélie Di Bartolomeo +6 more
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Reproductive Biology and Endocrinology, 2021 Background Blood coagulation has been associated with ovulation and female infertility. In this study, the expression of the tissue factor system was examined during ovulation in immature rats; the correlation between tissue factor and ovarian ...
You Jee Jang +6 more
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Propofol promotes angiogenesis in rats with postmenopausal osteoporosis [PDF]
Jichu yixue yu linchuang, 2023 Objective To investigate the impact of propofol on angiogenesis in postmenopausal osteoporosis (PMOP) rats and the role of Wnt/β-catenin signal pathway in this process. Methods Female Wistar rats were randomly grouped into sham operation group,
ZHAO Xiaoqi, DONG Xin, LIU Cong, REN Pengcheng, ZHANG Liang
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