Results 11 to 20 of about 661,753 (260)
Tissue factor and tissue factor pathway inhibitor [PDF]
Anaesthesia, 2004 Summary The classical ‘cascade/waterfall’ hypothesis formulated to explain in vitro coagulation organised the amplification processes into the intrinsic and extrinsic pathways.
G C, Price, S A, Thompson, P C A, Kam
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Tissue factor pathway inhibitor [PDF]
European Journal of Biochemistry, 2002 We have analyzed several mathematical models that describe inhibition of the factor VIIa–tissue factor complex (VIIa–TF) by tissue factor pathway inhibitor (TFPI). At the core of these models is a common mechanism of TFPI action suggesting that only the Xa–TFPI complex is the inhibitor of the extrinsic tenase activity.
Mikhail A, Panteleev +2 more
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Heparanase and Coagulation–New Insights
Rambam Maimonides Medical Journal, 2014 Heparanase, a β-D-endoglucuronidase abundant in platelets that was discovered 30 years ago, is an enzyme that cleaves heparan sulfate side chains on the cell surface and in the extracellular matrix. It was later recognized as being a pro-inflammatory and
Yona Nadir
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Heparanase—A Link between Coagulation, Angiogenesis, and Cancer
Rambam Maimonides Medical Journal, 2012 Heparanase that was cloned from and is abundant in the placenta is implicated in cell invasion, tumor metastasis, and angiogenesis. Recently we have demonstrated that heparanase may also affect the hemostatic system in a non-enzymatic manner.
Yona Nadir, Benjamin Brenner
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Gla-domainless factor Xa: molecular bait to bypass a blocked tenase complex
Haematologica, 2012 Background Hemophilia is caused by deficiencies in coagulation factor VIII or IX, resulting in direct blockade of the intrinsic tenase complex and indirect blockade of the extrinsic tenase complex which is rapidly inhibited upon binding of factor Xa to ...
Raphaël Marlu, Benoît Polack
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The abnormalities of coagulation and fibrinolysis in acute lung injury caused by gas explosion
Kaohsiung Journal of Medical Sciences, 2020 Acute lung injury (ALI) caused by gas explosion is common, and warrants research on the underlying mechanisms. Specifically, the role of abnormalities of coagulation and fibrinolysis in this process has not been defined.
Lin‐Qiang Tian +14 more
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Biology of tissue factor pathway inhibitor
Blood, 2014 AbstractRecent studies of the anticoagulant activities of the tissue factor (TF) pathway inhibitor (TFPI) isoforms, TFPIα and TFPIβ, have provided new insight into the biochemical and physiological mechanisms that underlie bleeding and clotting disorders. TFPIα and TFPIβ have tissue-specific expression patterns and anticoagulant activities.
Wood, J. +3 more
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Frontiers in Oncology, 2020 Factor V (FV) is a critical component in the blood coagulation cascade. In patients, FV inhibitors have been reported to be associated with malignancy. FV is present in plasma and platelets, which exhibit physical and functional differences. However, the
Xin Deng +18 more
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Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI. [PDF]
PLoS ONE, 2016 Factor (F) XI supports both normal human hemostasis and pathological thrombosis. Activated FXI (FXIa) promotes thrombin generation by enzymatic activation of FXI, FIX, FX, and FV, and inactivation of alpha tissue factor pathway inhibitor (TFPIα), in ...
Cristina Puy +7 more
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Research progress on clinical application of anti-tissue factor pathway inhibitor in hemophilia [PDF]
Zhenduanxue lilun yu shijianIn recent years， to address the unmet needs in hemophilia treatment， significant research has led to unprecedented advances in pharmacotherapy， including the development of several innovative mechanism-based therapies that restore hemostatic balance by ...
XIAO Jianwen, YI Weijia
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