Results 61 to 70 of about 948,853 (295)

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Tissue factor pathway inhibitor and bacterial infection [PDF]

Journal of Thrombosis and Haemostasis, 2011
See also van den Boogaard FE, Brands X, Schultz MJ, Levi M, Roelofs JJTH, van 't Veer C, van der Poll T. Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia. This issue, pp 122-32.
S A, Maroney, A E, Mast
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Similar hypercoagulable state and thrombosis risk in type I and type III protein S-deficient individuals from families with mixed type I/III protein S deficiency

Haematologica, 2010
Background Protein S, which circulates in plasma in both free and bound forms, is an anticoagulant protein that stimulates activated protein C and tissue factor pathway inhibitor.
Elisabetta Castoldi, Lisbeth F.A. Maurissen, Daniela Tormene, Luca Spiezia, Sabrina Gavasso, Claudia Radu, Tilman M. Hackeng, Jan Rosing, Paolo Simioni   +8 more
doaj   +1 more source

Intact Fibroblast Growth Factor 23 Regulates Chronic Kidney Disease–Induced Myocardial Fibrosis by Activating the Sonic Hedgehog Signaling Pathway

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Clinically, myocardial fibrosis is one of the most common complications caused by chronic kidney disease (CKD). However, the potential mechanisms of CKD‐induced myocardial fibrosis have not been clarified.
Lanlan Li, Hua Gan
doaj   +1 more source

Matriptase regulates c-Met mediated proliferation and invasion in inflammatory breast cancer. [PDF]

, 2016
The poor prognosis for patients with inflammatory breast cancer (IBC) compared to patients with other types of breast cancers emphasizes the need to better understand the molecular underpinnings of this disease with the goal of developing effective ...
Boerner, Julie, Colombo, Éloïc, Duhaime, Michael J, Hyland, Thomas E, Johnson, Michael D, Lang, Julie E, Leduc, Richard, Lin, Chen-Yong, List, Karin, Marsault, Eric, Tanabe, Lauren M, Zoratti, Gina L   +11 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source