Proteomic signatures of equine dental tooth tissues in ageing and disease
Equine Veterinary Journal, EarlyView.Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen +8 more
wiley +1 more source
Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and -9 to PMN Surfaces. [PDF]
J Immunol, 2019 Wang X +5 more
europepmc +1 more source
An Ocular Surface‐Targeting Nucleic Acid Hydrogel for Efficient Dry Eye Disease Treatment
Exploration, EarlyView.A self‐assembled nucleic acid hydrogel modified with mucin‐1 (MUC1) aptamer is developed, which can actively target the mucin layer on the ocular surface and significantly extend its retention time after distillation. Inside the hydrogel, therapeutic siRNA is embedded and can effectively silence the inflammation gene expression, subsequently restoring ...
Yuhe Liu +12 more
wiley +1 more source
High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer. [PDF]
Cancer Immunol Immunother, 2019 Carpén T +10 more
europepmc +1 more source
Artificial Chlorella Biohybrids for Alleviation of Cartilage Degeneration in Osteoarthritis
Exploration, EarlyView.Artificial Chlorella biohybrids (Ch@P) alleviate cartilage degeneration and protect against OA progression by activating mitophagy and reprogramming glucose metabolism in chondrocytes, as well as inducing articular thermal stimulation under near infrared irradiation.
Yongyun Chang +19 more
wiley +1 more source
Exploration, EarlyView.Based on the interaction between the weakly cross‐linked disulfide bonds that break under stress and charge‐reversal messenger molecules, we herein achieved nanoparticle charge reversal under stress and constructed a stress‐responsive charge‐reversal hydrogel microsphere system using microfluidic technology.
Feng Lin +11 more
wiley +1 more source
Tissue Inhibitor of Metalloproteinase-1: Actions beyond Matrix Metalloproteinase Inhibition. [PDF]
Cardiology, 2015 Lindsey ML, Yabluchanskiy A, Ma Y.
europepmc +1 more source
Extracellular Vesicle‐Based Therapies for Osteoarthritis—Advances, Challenges and Hopes
Exploration, EarlyView.Recent advances, challenges and hopes in using extracellular vesicles (EVs) as therapeutics for osteoarthritis. Recent advances include native and engineered EVs and translational developments. Challenges include cell sources and targeted effects of EVs, as well as establishing robust critical quality attributes, while hopes for advancing this field ...
Jiao Jiao Li, Wei Seong Toh
wiley +1 more source
Increased matrix metalloproteinase-9 to tissue inhibitor of metalloproteinase-1 ratio in smokers with airway hyperresponsiveness and accelerated lung function decline. [PDF]
Int J Chron Obstruct Pulmon Dis, 2018 Lo CY +8 more
europepmc +1 more source