Results 221 to 230 of about 174,743 (266)

Decreased Expression of Tissue Inhibitor of Metalloproteinase 1 in Stunned Myocardium

Journal of Surgical Research, 1998
Ultrastructural studies of stunned myocardium have shown disorganization and loss of extracellular collagen and increased collagenase activity early after ischemia and reperfusion. The interplay between matrix metalloproteinase 1 (MMP-1) and tissue inhibitor of metalloproteinase 1 (TIMP-1) regulates the turnover of cardiac extracellular matrix ...
K, Baghelai, R, Marktanner, J B, Dattilo, M P, Dattilo, E R, Jakoi, D R, Yager, R G, Makhoul, A S, Wechsler   +7 more
openaire   +2 more sources

Purification and secondary structural analysis of tissue inhibitor of metalloproteinases- 1

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1994
In connective tissue diseases such as rheumatoid arthritis, the matrix metalloproteinases are the primary enzymes involved in tissue degradation. Tissue inhibitor metalloproteinases-1 (TIMP-1) is a specific inhibitor of these enzymes, which is thought to regulate their action in vivo.
D J, Hodges, D C, Lee, C J, Salter, D G, Reid, G P, Harper, T E, Cawston   +5 more
openaire   +2 more sources

Tissue Inhibitor of Metalloproteinase-1 Protects Human Breast Epithelial Cells from Extrinsic Cell Death: A Potential Oncogenic Activity of Tissue Inhibitor of Metalloproteinase-1

Cancer Research, 2005
Abstract Tissue inhibitors of metalloproteinases (TIMPs) inhibit matrix metalloproteinases and some members of a disintegrin and metalloproteinase domain (ADAM) family. In addition, recent studies unveiled novel functions of TIMPs in the regulation of apoptosis.
Xu-Wen, Liu, Marcus E, Taube, Ki-Kyung, Jung, Zhong, Dong, Yong J, Lee, Stefanie, Roshy, Bonnie F, Sloane, Rafael, Fridman, Hyeong-Reh Choi, Kim   +8 more
openaire   +2 more sources

Tissue inhibitor of metalloproteinase 1 inhibits excitotoxic cell death in neurons

Molecular and Cellular Neuroscience, 2003
The upregulation of TIMP-1 following an excitotoxic injury has recently been hypothesized to be part of a general neuronal response that mediates long-lasting changes involved in tissue reorganization and possibly neuroprotection. In this study we have shown for the first time that within hours of applying TIMP-1 in recombinant form or by adenovirus ...
Tan, HK, Heywood, DJ, Ralph, GS, Bienemann, AS, Baker, AH, Uney, JB   +5 more
openaire   +3 more sources

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Journal of Nanjing Medical University, 2007
Objective: To explore the role of matrix metalloproteinase-1, 2 (MMP-1, MMP-2) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) in endometriosis. Methods: The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.
Rong Liu, Demin Pu, Dan Yang
openaire   +1 more source

Molecular characteristics of equine stromelysin and the tissue inhibitor of metalloproteinase 1

American Journal of Veterinary Research, 1998
Abstract Objective To clone the entire coding sequence of equine matrix metalloproteinase-3 (MMP-3, stromelysin) and tissue inhibitor of metalloproteinase-1 (TIMP-1 ) and compare their nucleotide and amino acid sequences with those of MMP-3 and TIMP-1 from other species.
D W, Richardson, G R, Dodge
openaire   +2 more sources

Salivary tissue inhibitor of metalloproteinases-1 localization and glycosylation profile analysis.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2011
Salivary tissue inhibitor of metalloproteinases-1 (TIMP-1) has been associated with pathological conditions in the oral cavity, but the origin of TIMP-1 in saliva remains unknown. Hence, we studied the localization of TIMP-1 in salivary gland tissue and also investigated if TIMP-1 found in blood and saliva is identical.
Holten-Andersen, Lars, Thaysen-Andersen, Morten, Jensen, Siri Beier, von Buchwald, Christian, Højrup, Peter, Offenberg, Hanne Kjær, Nielsen, Hans Jørgen, Brünner, Nils, Nauntofte, Birgitte, Reibel, Jesper   +9 more
openaire   +4 more sources

Tissue inhibitor of metalloproteinases-1 in the postoperative monitoring of colorectal cancer

European Journal of Cancer, 2006
The aim of this study was to investigate whether the pre- and postoperative plasma levels of tissue inhibitor of metalloproteinases-1 (TIMP-1) were associated with outcome in colorectal cancer (CRC). Pre- and postoperative plasma TIMP-1 from 280 curatively resected CRC patients and carcinoembryonic antigen (CEA) in corresponding serum samples were ...
Holten-Andersen, Mads Nikolaj, Nielsen, Hans Jørgen, Sørensen, Steen, Jensen, Vibeke, Brünner, Nils, Christensen, Ib Jarle   +5 more
openaire   +3 more sources

Significance of serum tissue inhibitor of metalloproteinases-1 in various liver diseases

Journal of Hepatology, 1996
This study was performed to assess the significance of elevated serum tissue inhibitor of metalloproteinases-1 concentration in various liver diseases.Tissue inhibitor of metalloproteinases-1 levels were measured in patients with various liver diseases, and were compared with serum type III procollagen-N-peptide (P III P), type IV collagen and laminin ...
T, Ueno, S, Tamaki, H, Sugawara, S, Inuzuka, T, Torimura, M, Sata, K, Tanikawa   +6 more
openaire   +2 more sources

Production of tissue inhibitor of metalloproteinase-1 and -2 by cultured keratinocytes

Journal of Dermatological Science, 2000
The imbalance between metalloproteinases and their inhibitors in tissue remodelling is likely to play an important role in various pathologic conditions. In order to understand the role of keratinocytes in regulating extracellular matrix degradation in skin, we analyzed the production of metalloproteinase inhibitors in keratinocytes.
Y, Sugita, E, Morita, T, Tanaka, K, Nakamura, S, Yamamoto   +4 more
openaire   +2 more sources