Results 91 to 100 of about 116,173 (199)

Regulation of the synthesis of tissue inhibitors of metalloproteinase-1 and -2 by hepatic and pancreatic stellate cells

, 2010
Hepatic stellate cells (HSC) play a central role in fibrosis development by production of extracellular matrix and also by secretion of matrix metalloproteinases (MMPs) and Tissue inhibitors of metalloproteinases (TIMPs) including TIMP-2 and MMP-2.
McCrudden, Peter Raymond
core  

Circulating interleukin-6 (IL-6) levels are associated with aortic dimensions in genetic aortic conditions.

PLoS ONE, 2019
BackgroundBiomarkers that reflect progression of dilatation of the aorta in patients with aortic conditions are needed as surrogate tools to assist in monitoring the condition in a non-invasive manner in combination with imaging procedures.
Daishi Fujita, Liliana Preiss, Kenichi Aizawa, Federico Asch, Kim Eagle, Toru Suzuki, GenTAC registry investigators   +6 more
doaj   +1 more source

Inhibition of Trophoblast-Induced Spiral Artery Remodeling Reduces Placental Perfusion in Rat Pregnancy.

, 2010
Rats harboring the human angiotensinogen and human renin genes develop preeclamptic features in pregnancy. The preeclamptic rats exhibit a deeper trophoblast invasion associated with a reduced resistance index by uterine Doppler.
Muller, DN, Cartwright, JE, Pijnenborg, R, Pijnenborg, R., Stefan Verlohren, Luft, F.C., Mueller, D.N., Lydia Hering, Morton, J., Davidge, ST, Dechend, R, Geusens, N, Robert Pijnenborg, Herse, F, Judith E. Cartwright, Herse, F., Florian Herse, Ralf Dechend, Dudenhausen, J.W., Nele Geusens, Cartwright, J.E., Geusens, N., Verhaegen, I., Jude Morton, Morton, J, Hering, L, Iris Verhaegen, Dominik N. Muller, Dechend, R., Sandra T. Davidge, Joachim W. Dudenhausen, Hering, L., Davidge, S.T., Verlohren, S, Verhaegen, I, Dudenhausen, JW, Friedrich C. Luft, Verlohren, S., Luft, FC   +38 more
core   +1 more source

Prognostic value of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in bladder carcinoma.

Chinese medical journal, 2002
To detect the level of matrix metalloproteinase-2 (MMP-2) mRNA and the tissue inhibitor of metalloproteinase-2 (TIMP-2) mRNA in bladder transitional cell carcinoma (BTCC), and to estimate the prognosis for bladder tumor based on the quality and quantity of MMP-2 and TIMP-2 mRNA.Thirty-five samples of human BTCC and 15 normal fresh bladder tissues were ...
Kexin, Xu, Shukun, Hou, Zhijun, Du
openaire   +1 more source

Perturbed CD81 in lung-cancer-derived extracellular vesicles modifies its function in cancer pathophysiology

Molecular Therapy: Oncology
Lung cancer (LC) remains a leading cause of cancer-related fatalities, necessitating an urgent need for potent treatment strategies. This study investigates the role of extracellular vesicle (EV) cargo: CD81 in lung cancer progression and its potential ...
Anjugam Paramanantham, Siddharth Das, Rahmat Asfiya, Yariswamy Manjunath, Gregory Goetz, Grace McCully, Hu Huang, Jussuf T. Kaifi, Akhil Srivastava   +8 more
doaj   +1 more source

Clinical significance of serum levels of matrix metalloproteinase 2 (MMP-2) and its tissue inhibitor (TIMP-2) in gastric cancer

Folia Histochemica et Cytobiologica, 2011
Matrix metalloproteinase 2 (MMP-2) is able to degrade type IV collagen, and thus plays a key role in the migration of tumor cells. MMP-2 activity is inhibited by its tissue inhibitor (TIMP-2).
Maciej Szmitkowski, Bogusław Kędra, Mariusz Gryko, Marta Łukaszewicz-Zając, Barbara Mroczko   +4 more
doaj   +1 more source

JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells

Journal of Biomedical Science, 2011
Background Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular
Chen Wei-Kung, Chen Li-Mien, Kuo Wei-Wen, Lin Yueh-Min, Hu Wei-Syun, Hsu Hsi-Hsien, Hwang Jin-Ming, Tsai Fuu-Jen, Liu Chung-Jung, Huang Chih-Yang   +9 more
doaj   +1 more source

Matrix metalloproteinase and tissue inhibitor expression in atherosclerotic and nonatherosclerotic thoracic aortic aneurysms

, 2007
ObjectivesThe altered expression of matrix metalloproteinases and their inhibitors influences the formation of atherosclerotic abdominal aortic aneurysms. Their association with thoracic aneurysms is less clear.
Howard, Alan, Schmoker, Joseph D., Trombley, Lucy, McPartland, Kenneth J., Terrien, Christopher, Ittleman, Frank P., Stanley, Andrew, Fellinger, Erika K., Boyum, Jon   +8 more
core   +1 more source

Matrix metalloproteinase-2, membranous type 1 matrix metalloproteinase, and tissue inhibitor of metalloproteinase-2 expression in ectopic and eutopic endometrium

, 2018
Objective: To investigate expression of matrix metalloproteinase-2 (MMP-2), membranous type 1 matrix metalloproteinase (MT1-MMP), and tissue inhibitor of metalloproteinase-2 (TIMP-2) in ectopic and eutopic endometrium from women with and without ...
정혜원, 문혜성
core   +1 more source

[Corrigendum] Human papillomavirus E6‑regulated microRNA‑20b promotes invasion in cervical cancer by targeting tissue inhibitor of metalloproteinase 2. [PDF]

Mol Med Rep, 2023
Cheng Y, Geng L, Zhao L, Zuo P, Wang J.
europepmc   +1 more source