Results 161 to 170 of about 157,447 (201)

The role of ADAM8 in intrahepatic cholangiocarcinoma. [PDF]

Discov Oncol
Cui X, Wang Z, Wang C, Jiang M, Song X, Liu Y, Deng X, Wang X, Zhang Y.   +8 more
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Matrix metalloproteinase‐2 regulates the expression of tissue inhibitor of matrix metalloproteinase‐2

Clinical and Experimental Pharmacology and Physiology, 2010
Summary1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation and activity of MMP‐2 are regulated by the intrinsic tissue inhibitor of MMP‐2 (TIMP‐2). The aim of the present study was to examine whether, conversely, MMP‐2 can affect the gene and protein expression of TIMP‐2.2.
Kaoru, Kimura, Xian Wu, Cheng, Kae, Nakamura, Aiko, Inoue, Lina, Hu, Haizhen, Song, Kenji, Okumura, Akihisa, Iguchi, Toyoaki, Murohara, Masafumi, Kuzuya   +9 more
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Endometrial tumor invasiveness is related to metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 expressions

International Journal of Gynecological Cancer, 2006
Matrix metalloproteinase (MMPs) expression has been linked to gynecological tumor aggressiveness. The objective of this study was to determine MMP-2, MMP-7, and MMP-9 and tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 expression in endometrial malignancies and their relation to clinical and histologic parameters.
Graesslin, Olivier, Cortez, Annie, Uzan, C., Birembaut, Philippe, Quereux, Christian, Daraï, Emile   +5 more
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Erythropoietin Modulates Imbalance of Matrix Metalloproteinase-2 and Tissue Inhibitor of Metalloproteinase-2 in Doxorubicin-induced Cardiotoxicity

Heart, Lung and Circulation, 2014
Doxorubicin (DOX) is a highly effective anti-cancer drug with limited clinical use due to its serious cardiotoxicity. Recent studies reported that erythropoietin (EPO) could exert a cardioprotective effect by non-erythropoietic effects. This study was to investigate fibrosis of DOX-induced cardiotoxicity and determine mechanisms of EPO against ...
Xing, Chen, Zhihua, Guo, Peixian, Wang, Miqing, Xu   +3 more
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Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2)

Journal of Cell Science, 1994
ABSTRACT Human tissue inhibitor of metalloproteinases-2 (TIMP-2) has a potent growth-promoting activity for wide range of human, bovine and mouse cells, having an optimal concentration (10 ng/ml, 0.46 nM) that is ten-times lower than that of TIMP-1 (Hayakawa et al. (1992)FEBS Lett. 298, 29).
T, Hayakawa, K, Yamashita, E, Ohuchi, A, Shinagawa   +3 more
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Polymorphisms in the matrix metalloproteinase‐2 and tissue inhibitor of metalloproteinase‐2 and the risk of human adenomyosis

Environmental and Molecular Mutagenesis, 2008
AbstractThe matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) may contribute to the development of adenomyosis. The aim of the present study was to investigate whether three single nucleotide polymorphisms (SNPs) in the promoter regions of MMP‐2 (−1306C/T and −735C/T) and TIMP‐2 (‐418G/C) genes were related to the risk
Shan, Kang, Xiwa, Zhao, Huimin, Xing, Na, Wang, Rongmiao, Zhou, Shucheng, Chen, Wansheng, Li, Jian, Zhao, Yanan, Duan, Donglan, Sun, Yan, Li   +10 more
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Host expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in normal colon tissue affects metastatic potential of colorectal cancer

Diseases of the Colon & Rectum, 1999
To clarify the mechanism of cancer cell invasion, we paid close attention to the role of matrix metalloproteinases and tissue inhibitors of metalloproteinases in normal tissue that is located in the same organ as the cancer.Samples were obtained from a tumor lesion and normal tissue in the resected large intestine of 59 patients with colorectal cancer,
H, Masuda, H, Aoki
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Matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in fetal rabbit lung

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2000
Cell-extracellular matrix interaction and extracellular matrix remodeling are known to be important in fetal lung development. We investigated the localization of matrix metalloproteinases (MMPs) in fetal rabbit lungs. Immunohistochemistry for type IV collagen, MMP-1, MMP-2, MMP-9, membrane type (MT) 1 MMP, and tissue inhibitor of metalloproteinase ...
Y, Fukuda, M, Ishizaki, Y, Okada, M, Seiki, N, Yamanaka   +4 more
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Tissue inhibitor of matrix metalloproteinase-2 in nasopharyngeal carcinoma.

MedGenMed : Medscape general medicine, 2008
By regulating matrix metalloproteinase (MMP) activity and controlling the breakdown of extracellular matrix components, tissue inhibitors of metalloproteinases (TIMPs) play an important role in the process of tumor invasion and metastasis. The present study was designed to clarify the role of TIMP-2 in nasopharyngeal carcinoma (NPC) patients and to ...
Amr Ahmed, El Badry, Amal Abou, El-Fadle, Abdel Latif, El-Balshy   +2 more
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Tissue Inhibitor of Metalloproteinase 2 and Coronary Artery Lesions in Kawasaki Disease

The Journal of Pediatrics, 2007
To identify cytokine genes uniquely expressed in peripheral blood mononuclear cells (PBMNCs) in the acute phase of Kawasaki disease (KD) with coronary artery lesions (CALs).We screened the mRNA expression levels of PBMNCs from 4 pairs of KD patients with and without CAL using DNA microarray.
Kenji, Furuno, Hidetoshi, Takada, Ken, Yamamoto, Kazuyuki, Ikeda, Takuro, Ohno, Vahid, Khajoee, Yumi, Mizuno, Toshiro, Hara   +7 more
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