Application of Peptides Containing the Cleavage Sequence of Pro-TNFα in Assessing TACE Activity of Whole Cells [PDF]
, 2002 Tumor necrosis factor-α (TNFα) is presumably shed from cell membranes by TNFα-cleaving enzyme (TACE). The peptides SPLAQAVRSSSR and Dabcyl-LAQAVRSSSR-Edans, each encompassing the cleavage sequence of pro-TNFα recognized by TACE, were applied to intact ...
Becker, Bernhard F. +3 more
core +1 more source
BMC Cancer, 2006 Background Matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), and urokinase-type plasminogen activator (uPA) are involved in colorectal cancer invasion and metastasis.
Lim Kyu +7 more
doaj +1 more source
Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. [PDF]
, 2016 BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall.
Hashimoto, Tomoki +9 more
core +2 more sources
Clinical Ophthalmology, 2014 Selcuk Kara,1 Nilgun Yildirim,2 Ahmet Ozer,2 Omer Colak,3 Afsun Sahin21Department of Ophthalmology, Canakkale Onsekiz Mart University School of Medicine, Canakkale, 2Department of Ophthalmology, Eskisehir Osmangazi University Hospitals, Meselik ...
Kara S +4 more
doaj
Alʹmanah Kliničeskoj Mediciny, 2018 Background: Over the last 10 years the incidence of gastric cancer has declined significantly. Nevertheless, it remains one of the most prevalent malignancies both in Russia and worldwide.
E. S. Gershtein +6 more
doaj +1 more source
Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. [PDF]
, 2006 BackgroundGlomerular basement membrane (GBM), a key component of the blood-filtration apparatus in the in the kidney, is formed through assembly of type IV collagen with laminins, nidogen, and sulfated proteoglycans.
Cosgrove, Dominic +8 more
core +3 more sources
Interaction between tissue inhibitor of metalloproteinases-2 and progelatinase A: immunoreactivity analyses [PDF]
Biochemical Journal, 1996 By immunoreactivity analysis using monoclonal antibodies, we showed that the C-terminal domain [R415–631; R is residue] of progelatinase A [pro-matrix metalloproteinase-2 (proMMP-2); EC 3.4.24.24] affected the immunoreactivity of a one-step sandwich enzyme immunoassay (sandwich EIA) for tissue inhibitor of metalloproteinases-2 (TIMP-2) in exactly the ...
N, Fujimoto +5 more
openaire +2 more sources
TIMP3 interplays with apelin to regulate cardiovascular metabolism in hypercholesterolemic mice [PDF]
, 2015 Tissue inhibitor of metalloproteinase 3 (TIMP3) is an extracellular matrix (ECM) bound protein, which has been shown to be downregulated in human subjects and experimental models with cardiometabolic disorders, including type 2 diabetes mellitus ...
Arisi, I +14 more
core +4 more sources
Correlation of Matrix Metalloproteinases and Tissue Inhibitors of Matrix Metalloproteinase Expression in Ileal Carcinoids, Lymph Nodes and Liver Metastasis with Prognosis and Survival [PDF]
, 2009 Purpose: Ileal carcinoids are gut epithelial tumors originating from serotonin-containing enterochromaffin (EC) cells. Therapeutic options for effectively inhibiting the growth and spread of metastatic carcinoids are still limited.
Baur, Dorothee M. +8 more
core +2 more sources
Cancer Management and Research, 2019 Wen-jing Zhang, Bing Song, Tao Yang Department of General Surgery, Tianjin First Central Hospital, Tianjin 300192, People’s Republic of ChinaCorrespondence: Bing Song Email song2002bing@163.comIntroduction: The objective of this study was to assess
Zhang W, Song B, Yang T
doaj