Results 81 to 90 of about 153,944 (203)

Application of Peptides Containing the Cleavage Sequence of Pro-TNFα in Assessing TACE Activity of Whole Cells [PDF]

, 2002
Tumor necrosis factor-α (TNFα) is presumably shed from cell membranes by TNFα-cleaving enzyme (TACE). The peptides SPLAQAVRSSSR and Dabcyl-LAQAVRSSSR-Edans, each encompassing the cleavage sequence of pro-TNFα recognized by TACE, were applied to intact ...
Becker, Bernhard F., Gilles, Stefanie, Sommerhoff, Christian P., Zahler, Stefan   +3 more
core   +1 more source

Tissue inhibitor of metalloproteinase-2(TIMP-2)-deficient mice display motor deficits [PDF]

Journal of Neurobiology, 2005
The degradation of the extracellular matrix is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Matrix components of the basement membrane play critical roles in the development and maintenance of the neuromuscular junction (NMJ), yet almost nothing is known about the regulation of MMP and TIMP ...
Diane M, Jaworski, Paul, Soloway, John, Caterina, William A, Falls   +3 more
openaire   +2 more sources

Protective Role of Matrix Metalloproteinase-2 in Allergic Bronchial Asthma

Frontiers in Immunology, 2019
Inflammation, reversible obstruction, and hyperresponsiveness of the airways are characteristic findings of bronchial asthma. Several evidence has demonstrated the involvement of matrix metalloproteinase-2 in allergic airway inflammation.
Yoshinori Takahashi, Tetsu Kobayashi, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Kentaro Fujiwara, Tomohito Okano, Hajime Fujimoto, Kentaro Asayama, Atsuro Takeshita, Atsuro Takeshita, Taro Yasuma, Taro Yasuma, Kota Nishihama, Ryo Inoue, Liqiang Qin, Yoshiyuki Takei, Osamu Taguchi, Esteban C. Gabazza   +17 more
doaj   +1 more source

Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients.

Folia Histochemica et Cytobiologica, 2011
The aim of the study was to assess the importance of the measurement of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in patients with colorectal cancer (CRC) in relation to clinicopathological features ...
Barbara Mroczko, Magdalena Groblewska, Mariusz Gryko, Bogusław Kędra, Maciej Szmitkowski   +4 more
doaj   +1 more source

Angiotensin Type 2 Receptor Stimulation Ameliorates Left Ventricular Fibrosis and Dysfunction via Regulation of Tissue Inhibitor of Matrix Metalloproteinase 1/Matrix Metalloproteinase 9 Axis and Transforming Growth Factor β1 in the Rat Heart [PDF]

, 2014
Left ventricular (LV) remodeling is the main reason for the development of progressive cardiac dysfunction after myocardial infarction (MI). This study investigated whether stimulation of the angiotensin type 2 receptor is able to ameliorate
Dahlöf, Bjorn, Hallberg, Anders, Kaschina, Elena, Kintscher, Ulrich, Lauer, Dilyara, Sharkovska, Yuliya, Slavic, Svetlana, Sommerfeld, Manuela, Steckelings, Ulrike Muscha, Thöne-Reineke, Christa, Unger, Thomas   +10 more
core   +2 more sources

Characterization of the functional domain of tissue inhibitor of metalloproteinases-2 (TIMP-2) [PDF]

Biochemical Journal, 1993
Analysis of the functional domain of tissue inhibitor of metallo-proteinases-2 (TIMP-2) was performed using limited proteolytic degradation with trypsin. This treatment generated a 13.5 kDa fragment which was purified and shown to consist of an uncleaved N-terminal region extending from residue 1 to residue 132.
Y A, DeClerck, T D, Yean, Y, Lee, J M, Tomich, K E, Langley   +4 more
openaire   +2 more sources

Matrix metalloproteinase-2, -9, and tissue inhibitor of MMP-2 gene polymorphisms in Taiwanese periodontitis patients

Journal of Dental Sciences, 2016
Background/purpose: Matrix metalloproteinases (MMPs) and tissue inhibitor of MMPs (TIMPs) have been shown to play an important role in the pathogenesis of tissue destruction in periodontitis. The associations between single nucleotide polymorphisms (SNPs)
Yu-Feng Hsiao, Li-Chiu Yang, Yu-Shian Chou, Ya-Ping Ho, Ying-Chu Lin, Kun-Yen Ho, Yi-Min Wu, Chi-Cheng Tsai   +7 more
doaj   +1 more source

Cigarette Smoke Extract Stimulates MMP-2 Production in Nasal Fibroblasts via ROS/PI3K, Akt, and NF-κB Signaling Pathways

Antioxidants, 2020
Cigarette smoke exposure has been shown to be associated with chronic rhinosinusitis and tissue remodeling. The present study aimed to investigate the effects of cigarette smoke extract (CSE) on matrix metalloproteinase (MMP) and tissue inhibitor of ...
Joo-Hoo Park, Jae-Min Shin, Hyun-Woo Yang, Tae Hoon Kim, Seung Hoon Lee, Heung-Man Lee, Jae-Gu Cho, Il-Ho Park   +7 more
doaj   +1 more source

Tetracycline Actions Relevant to Rosacea Treatment [PDF]

, 2009
Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of
Korting, Hans Christian, Schöllmann, C.
core   +1 more source

PECULIARITIES OF THE FIBROSIS AND CIRRHOSIS MONITORING AMONG CHILDREN WITH CHRONIC LIVER DISEASES

Педиатрическая фармакология, 2009
The researchers examined the opportunities to use determination in the serum among children with chronic liver diseases of various etiologies of the hyaluronic acid levels, collagen type IV, matrix metalloproteinase-2, tissue inhibitor of the matrix ...
A.N. Surkov, I.E. Smirnov, A.S. Potapov, A.G. Kucherenko, E.L. Tumanova   +4 more
doaj   +2 more sources