Results 61 to 70 of about 93,976 (154)

Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling

Frontiers in Immunology, 2018
Airway remodeling is responsible for the progressive decline of lung function in bronchial asthma. Matrix metalloproteinase-2 and fibroblast-to-myofibroblast transition are involved in tissue remodeling.
Yu Kuwabara, Tetsu Kobayashi, Corina N. D'Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Kota Nishihama, Atsuro Takeshita, Hajime Fujimoto, Mizuho Nagao, Takao Fujisawa, Esteban C. Gabazza   +10 more
doaj   +1 more source

Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Dilated cardiomyopathy (DCM) is a common cause of heart failure in adult and pediatric patients, but the underlying mechanism may vary in adults and children, with few studies conducted to date.
Sayantan Jana, Hao Zhang, Gary D. Lopaschuk, Darren H. Freed, Consolato Sergi, Paul F. Kantor, Gavin Y. Oudit, Zamaneh Kassiri   +7 more
doaj   +1 more source

Circulating interleukin-6 (IL-6) levels are associated with aortic dimensions in genetic aortic conditions.

PLoS ONE, 2019
BackgroundBiomarkers that reflect progression of dilatation of the aorta in patients with aortic conditions are needed as surrogate tools to assist in monitoring the condition in a non-invasive manner in combination with imaging procedures.
Daishi Fujita, Liliana Preiss, Kenichi Aizawa, Federico Asch, Kim Eagle, Toru Suzuki, GenTAC registry investigators   +6 more
doaj   +1 more source

Prognostic value of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in bladder carcinoma.

Chinese medical journal, 2002
To detect the level of matrix metalloproteinase-2 (MMP-2) mRNA and the tissue inhibitor of metalloproteinase-2 (TIMP-2) mRNA in bladder transitional cell carcinoma (BTCC), and to estimate the prognosis for bladder tumor based on the quality and quantity of MMP-2 and TIMP-2 mRNA.Thirty-five samples of human BTCC and 15 normal fresh bladder tissues were ...
Kexin, Xu, Shukun, Hou, Zhijun, Du
openaire   +1 more source

Perturbed CD81 in lung-cancer-derived extracellular vesicles modifies its function in cancer pathophysiology

Molecular Therapy: Oncology
Lung cancer (LC) remains a leading cause of cancer-related fatalities, necessitating an urgent need for potent treatment strategies. This study investigates the role of extracellular vesicle (EV) cargo: CD81 in lung cancer progression and its potential ...
Anjugam Paramanantham, Siddharth Das, Rahmat Asfiya, Yariswamy Manjunath, Gregory Goetz, Grace McCully, Hu Huang, Jussuf T. Kaifi, Akhil Srivastava   +8 more
doaj   +1 more source

Clinical significance of serum levels of matrix metalloproteinase 2 (MMP-2) and its tissue inhibitor (TIMP-2) in gastric cancer

Folia Histochemica et Cytobiologica, 2011
Matrix metalloproteinase 2 (MMP-2) is able to degrade type IV collagen, and thus plays a key role in the migration of tumor cells. MMP-2 activity is inhibited by its tissue inhibitor (TIMP-2).
Maciej Szmitkowski, Bogusław Kędra, Mariusz Gryko, Marta Łukaszewicz-Zając, Barbara Mroczko   +4 more
doaj   +1 more source

JNK suppression is essential for 17β-Estradiol inhibits prostaglandin E2-Induced uPA and MMP-9 expressions and cell migration in human LoVo colon cancer cells

Journal of Biomedical Science, 2011
Background Epidemiological studies demonstrate that the incidence and mortality rates of colorectal cancer in women are lower than in men. However, it is unknown if 17β-estradiol treatment is sufficient to inhibit prostaglandin E2 (PGE2)-induced cellular
Chen Wei-Kung, Chen Li-Mien, Kuo Wei-Wen, Lin Yueh-Min, Hu Wei-Syun, Hsu Hsi-Hsien, Hwang Jin-Ming, Tsai Fuu-Jen, Liu Chung-Jung, Huang Chih-Yang   +9 more
doaj   +1 more source

[Corrigendum] Human papillomavirus E6‑regulated microRNA‑20b promotes invasion in cervical cancer by targeting tissue inhibitor of metalloproteinase 2. [PDF]

Mol Med Rep, 2023
Cheng Y, Geng L, Zhao L, Zuo P, Wang J.
europepmc   +1 more source

Engineered N-TIMP2 Variant Specifically Targeting MMP-9 Exhibits Potent Anti-Glioblastoma Activity

Biomolecules
Glioblastoma (GB) is the most aggressive form of brain cancer. However, despite intensive intervention, GB almost invariably recurs due to the highly invasive nature of its tumor cells, which infiltrate surrounding healthy brain tissue, underscoring the ...
Mark Feldman, Naama Rotenberg, Julia M. Shifman   +2 more
doaj   +1 more source

Matrix metalloproteinase 2 and tissue inhibitor of matrix metalloproteinases 2 in the diagnosis of colorectal adenoma and cancer patients

Folia Histochemica et Cytobiologica, 2010
The aim of the study was to assess the importance of the measurement of matrix metalloproteinase 2 (MMP-2)and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in patients with colorectal cancer (CRC) in relation to clinicopathologicalfeatures of ...
Magdalena Groblewska, Barbara Mroczko, Mariusz Gryko, Boguslaw Kędra, Maciej Szmitkowski   +4 more
doaj