Results 191 to 200 of about 158,026 (312)

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Mechanistic interplay between aflatoxin B1 and tissue inhibitor of metalloproteinase-3 in hepatocellular carcinoma. [PDF]

World J Hepatol
Luo Y, Wang LJ, Wang CL.
europepmc   +1 more source

Higher serum tissue inhibitor of metalloproteinase-1 predicts atrial fibrillation recurrence after radiofrequency catheter ablation. [PDF]

Front Cardiovasc Med, 2022
Li H, Sun W, Wang Z, Wang Z, Du X, Chen J, Gao J, Liu X, Wang X, Wang Y, Wu Y, Zhang X.   +11 more
europepmc   +1 more source

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

Glycosaminoglycan-functionalized hydrogels for sustained delivery of tissue inhibitor of metalloproteinase-3 mediating matrix metalloprotease inhibition and extracellular matrix stabilization. [PDF]

Bioact Mater
Junker F, Rupf S, Schindler PM, Wilden C, Hohl M, Ruiz-Gómez G, Pisabarro MT, Wrublewsky S, Bickelmann C, Berhorst C, Alansary D, Wieland B, Bischoff M, Lee PS, Moeller S, Berg A, Dancker TA, Lauterbach MA, Ganse B, Roma LP, Steudter T, Metzger W, Tschernig T, Ampofo E, Laschke MW, Hannig M, Rother S.   +26 more
europepmc   +1 more source

Deglycosylation Increases the Aggregation and Angiogenic Properties of Mutant Tissue Inhibitor of Metalloproteinase 3 Protein: Implications for Sorsby Fundus Dystrophy. [PDF]

Int J Mol Sci, 2022
Qi JH, Anand-Apte B.
europepmc   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Distinct endobronchial expression of matrix-metalloproteinases (MMP) and their endogenous inhibitors in lung cancer

Swiss Medical Weekly, 2001
F Reichenberger, C Wyser
doaj   +1 more source

Tissue inhibitor of metalloproteinase 1 promotes ferroptosis and suppresses prostate cancer metastasis. [PDF]

J Biol Chem
Rao Y, Pan Q, Liu S, Yao S, Li L, Yan J, Chen L, Xu L, Yan H, Ma A, Wang F, Mao X, Wang Z, Zhang J, Guo J, Sun Z.   +15 more
europepmc   +1 more source

Impact of Clinicopathological Characteristics and Tissue Inhibitor of Metalloproteinase-3 Polymorphism Rs9619311 on Biochemical Recurrence in Taiwanese Patients with Prostate Cancer. [PDF]

Int J Environ Res Public Health, 2022
Hsieh CY, Lin CY, Wang SS, Chou YE, Chien MH, Wen YC, Hsieh MJ, Yang SF.   +7 more
europepmc   +1 more source