Results 111 to 120 of about 166,146,473 (295)

Dynamic changes of serum matrix metalloproteinases and tissue inhibitors in Kawasaki disease: implications for coronary artery lesions persistence

Italian Journal of Pediatrics
Background The mechanism of coronary artery lesions (CALs) persistence in Kawasaki disease (KD) remains unclear. The study aimed to investigate the serum dynamic changes of matrix metalloproteinases (MPPs) and tissue inhibitors (TIMPs) in children with ...
Yaqi Li, Yao Lin, Chen Shen, Jing Zhang, Hui Wang, Qin Zhang, Lin Shi   +6 more
doaj   +1 more source

Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury

Brazilian Journal of Medical and Biological Research, 2000
Acute lung injury is characterized by a severe disruption of alveolo-capillary structures and includes a variety of changes in lung cell populations. Evidence suggests the occurrence of rupture of the basement membranes and interstitial matrix remodeling
M. Corbel, E. Boichot, V. Lagente
doaj   +1 more source

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]

, 2012
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Yu, Alice L., Welge-Lussen, Ulrich, Moriniere, Jerome   +2 more
core   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Potential Clinical Applications of Matrix Metalloproteinase Inhibitors and their Future Prospects

The International Journal of Biological Markers, 2013
Matrix metalloproteinases (MMPs) are endopeptidases that are involved in extracellular matrix degradation. They are also implicated in a number of abnormal bioprocesses, such as tumor growth, invasion, and metastasis.
Wenzhao Li, Shigehira Saji, Fumiaki Sato, Makoto Noda, Masakazu Toi   +4 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Matrix Metalloproteinase’s Role in Producing and Curing of Liver Fibrosis [PDF]

Cell Journal, 2009
Matrix metalloproteinases are a zinc and calcium dependent endopeptidase family that areexpressed in injured tissue such as cardiovascular or hepatic disease. Complex efforts of thisenzymes on the extra cellular matrix structure is related to up and down
Hossein Baharvand, Vahideh Rabani
doaj  

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

[Matrix metalloproteinases and their tissue inhibitors].

Postepy biochemii, 2013
Matrix metalloproteinases (MMPs), also known as matrixins are endoproteinases that degrading protein components of the extracellular matrix (ECM), cause its restoration and reconstruction. In this way, retain the appropriate structure of the ECM and basement membrane during both: physiological processes and pathological conditions.
openaire   +1 more source