Results 261 to 270 of about 100,799 (312)
Some of the next articles are maybe not open access.
Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease
2021Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways.
Oskar, Zakiyanov +3 more
openaire +2 more sources
Structural Basis of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases
Molecular Biotechnology, 2003The matrix metalloproteinases (MMPs) constitute a family of secreted/cell-surface-anchored multidomain zinc endopeptidases, all of which exhibit a catalytic domain of a common metzincin-like topology, and which are involved in degradation of the extracellular matrix but also in a number of other biologic processes. Normally, the proteolytic activity of
Maskos, K., Bode, W.
openaire +3 more sources
Journal of Endodontics, 2021
Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) are considered important mediators of the periapical immune response to infection. This study aimed to clarify the putative relationship between MMPs and TIMPs by elucidating the activity of MMP-1, MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in the temporal ...
Chun-Yan, Wan +5 more
openaire +2 more sources
Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) are considered important mediators of the periapical immune response to infection. This study aimed to clarify the putative relationship between MMPs and TIMPs by elucidating the activity of MMP-1, MMP-2, MMP-8, MMP-9, TIMP-1, and TIMP-2 in the temporal ...
Chun-Yan, Wan +5 more
openaire +2 more sources
Critical Reviews in Eukaryotic Gene Expression, 1997
Matrix metalloproteinases (MMPs) are enzymes with important roles in a variety of normal physiological processes; these same enzymes are also operative in a range of pathologies. The proteins known as the tissue inhibitors of matrix metalloproteinases (TIMPs) act to limit the enzymatic function of the MMPs. MMPs and TIMPs can be divided into two groups
P, Borden, R A, Heller
openaire +2 more sources
Matrix metalloproteinases (MMPs) are enzymes with important roles in a variety of normal physiological processes; these same enzymes are also operative in a range of pathologies. The proteins known as the tissue inhibitors of matrix metalloproteinases (TIMPs) act to limit the enzymatic function of the MMPs. MMPs and TIMPs can be divided into two groups
P, Borden, R A, Heller
openaire +2 more sources
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas
Journal of Neurosurgery, 1995✓ The gene expression of five matrix metalloproteinases (MMPs) and two tissue inhibitors of metalloproteinases (TIMPs) was studied in human gliomasin vivoandin vitroto evaluate their roles in glioma invasion. Simultaneous expression of one to four MMP genes and two TIMP genes was found in 17 surgical glioma specimens, and one MMP (gelatinase A) gene ...
A, Nakano +4 more
openaire +2 more sources
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in ovarian function
Reviews of Reproduction, 1998Growth and ovulation of follicles, and development, maintenance, and regression of the corpus luteum depend on cyclical remodelling of the extracellular matrix. The extracellular matrix consists of proteinaceous and non-proteinaceous components and provides the tissue-specific, extracellular architecture to which cells attach, and modulates the ...
E W, McIntush, M F, Smith
openaire +2 more sources
Journal of Andrology, 2002
ABSTRACTThe matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade protein components of the extracellular matrix. The necessity of breakdown of physical barriers in the fertilization process suggests that MMPs, along with their tissue inhibitors (TIMPs), might be involved in this task.
Orit, Buchman-Shaked +3 more
openaire +2 more sources
ABSTRACTThe matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade protein components of the extracellular matrix. The necessity of breakdown of physical barriers in the fertilization process suggests that MMPs, along with their tissue inhibitors (TIMPs), might be involved in this task.
Orit, Buchman-Shaked +3 more
openaire +2 more sources
Clinical and Experimental Pharmacology and Physiology, 2010
Summary1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation and activity of MMP‐2 are regulated by the intrinsic tissue inhibitor of MMP‐2 (TIMP‐2). The aim of the present study was to examine whether, conversely, MMP‐2 can affect the gene and protein expression of TIMP‐2.2.
Kaoru, Kimura +9 more
openaire +2 more sources
Summary1. Matrix metalloproteinases (MMP) are associated with the vascular remodelling seen in atherosclerosis and aneurysm. The activation and activity of MMP‐2 are regulated by the intrinsic tissue inhibitor of MMP‐2 (TIMP‐2). The aim of the present study was to examine whether, conversely, MMP‐2 can affect the gene and protein expression of TIMP‐2.2.
Kaoru, Kimura +9 more
openaire +2 more sources
Current Eye Research, 1998
To evaluate the roles of fibroblast proteins in the remodeling of the subconjunctival connective tissue, we immunohistochemically assessed the expression of matrix metalloproteinases (MMP)-1 and -2, and the tissue inhibitors of matrix metalloproteinases (TIMP)-1 and -2 in cultured human subconjunctival fibroblasts and in normal and healing human ...
Y, Kawashima +5 more
openaire +2 more sources
To evaluate the roles of fibroblast proteins in the remodeling of the subconjunctival connective tissue, we immunohistochemically assessed the expression of matrix metalloproteinases (MMP)-1 and -2, and the tissue inhibitors of matrix metalloproteinases (TIMP)-1 and -2 in cultured human subconjunctival fibroblasts and in normal and healing human ...
Y, Kawashima +5 more
openaire +2 more sources