Mechanobiological feedback loops and quantitative decision thresholds in organ fibrosis: Translational principles for antifibrotic therapy. [PDF]
Lonardo A, Weiskirchen R.
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SASP-mediated cellular senescence following myocardial infarction: from spatiotemporal immune regulation to therapeutic strategies. [PDF]
Zhang F, Liao Y, Yang P, Guo J.
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Myocardial Fibrosis in Cardiovascular Disease: An Integrative Biomarker-Imaging Framework Linking Molecular Mechanisms to Structural Phenotypes. [PDF]
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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human gliomas
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To evaluate the roles of fibroblast proteins in the remodeling of the subconjunctival connective tissue, we immunohistochemically assessed the expression of matrix metalloproteinases (MMP)-1 and -2, and the tissue inhibitors of matrix metalloproteinases (TIMP)-1 and -2 in cultured human subconjunctival fibroblasts and in normal and healing human ...
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Dysregulation of Matrix Metalloproteinases and their Tissue Inhibitors by S100A4
Connective Tissue Research, 2008The S100A4 protein as well as the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are associated with diseases such as arthritis and cancer. This mini review focuses on in vitro and in vivo studies indicating S100A4 involvement in regulation of MMPs and TIMPs, and the biological and pathobiological consequences of this regulation.
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Tissue inhibitors of matrix metalloproteinases in cancer.
Tissue inhibitors of metalloproteinases (TIMPs) play a key regulatory role in the homeostasis of the extracellular matrix (ECM) by controlling the activity of matrix metalloproteinases (MMPs). Some TIMPs have a second function as well, unrelated to their antiMMP activity, which affects cell proliferation and survival.
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Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in kidney disease
2021Matrix metalloproteinases (MMPs) are a group of zinc and calcium endopeptidases which cleave extracellular matrix (ECM) proteins. They are also involved in the degradation of cell surface components and regulate multiple cellular processes, cell to cell interactions, cell proliferation, and cell signaling pathways.
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