Results 61 to 70 of about 100,799 (312)

Tendinopathy—from basic science to treatment [PDF]

, 2008
Chronic tendon pathology (tendinopathy), although common, is difficult to treat. Tendons possess a highly organized fibrillar matrix, consisting of type I collagen and various 'minor' collagens, proteoglycans and glycoproteins.
A McCormick, AH Drummond, AJ Banes, AN Bamji, AN Corps, AN Corps, AN Corps, AP D'Vaz, B Pasternak, BL Woodley, BM Clancy, CA Speed, D Bjur, EM Badley, G Puddu, G Riley, GAC Murrell, GC Jones, GC Jones, GP Riley, GP Riley, Graham Riley, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Langberg, H Langberg, H Langberg, H Nagase, HA Awad, J Archambault, JA Paoloni, JA Paoloni, JA Paoloni, JD Rompe, JE Carpenter, JL Cook, JM Archambault, L Józsa, L Ohberg, LC Almekinders, LJ McCawley, M Aström, M Benjamin, M Gotoh, M Gotoh, M Lavagnino, M Lavagnino, MD Chard, ME Jones, MH Khan, N Mafi, P Burssens, P Kannus, R Salingcarnboriboon, RA Bank, RF Ker, RK Smith, SA Fenwick, SC Fu, SG Rees, SP Arnoczky, T Pufe, T Pufe, T Samiric, TG Gerich, TW Ehlers, UM Wewer   +69 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Mesenchymal Stem Cell Treatment Prevents Post-Stroke Dysregulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases

Cellular Physiology and Biochemistry, 2017
Background/Aims: Stem cell treatment is one of the potential treatment options for ischemic stroke. We recently demonstrated a protective effect of human umbilical cord blood-derived mesenchymal stem cells (HUCB-MSCs) in a rat model of ischemic stroke ...
Bharath Chelluboina, Koteswara Rao Nalamolu, Gustavo G. Mendez, Jeffrey D. Klopfenstein, David M Pinson, David Z Wang, Krishna Kumar Veeravalli   +6 more
doaj   +1 more source

Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases. [PDF]

, 2016
BACKGROUND: Emphysema is characterised by distinct pathological sub-types, but little is known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extracellular matrix and have been ...
Bourne, S, Coombs, NA, Elkington, PT, Estepar, RS, Harden, S, Kim, V, Ostridge, K, Staples, KJ, Washko, G, Wilkinson, TM, Williams, N   +10 more
core   +1 more source

Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in the hair cycle

Experimental and Therapeutic Medicine, 2016
According to the growth state of hair follicles, the hair cycle is divided into the anagen, catagen and telogen phases. A number of biological factors have been shown to synchronize with the hair cycle. As an important component of the hair follicle, the extracellular matrix is regulated by matrix metalloproteinases (MMPs) and their inhibitors (tissue ...
HOU, CHUN, MIAO, YONG, WANG, XUE, CHEN, CHAOYUE, LIN, BOJIE, HU, ZHIQI   +5 more
openaire   +3 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Significance of matrix metalloproteinases and their ihhibitors in normal subjects, solid and blood cancer patients

Терапевтический архив, 2009
Matrix metalloproteinases and their inhibitors play an essential role in invasion and dissemination of malignant tumors. The study of expression of MMP and their inhibitors in solid and blood cancer may appear a key study giving assessment of antitumor ...
Nadezhda Vladimirovna Gaydamaka, Elena Nikolaevna Parovichnikova, Larisa Eduardovna Zavalishina, Valeriy Grigor'evich Savchenko, Georgiy Avraamovich Frank, N V Gaidamaka, E N Parovichnikova, L E Zavalishina, V G Savchenko, G A Frank   +9 more
doaj  

Overexpression of MMPs in Corneas Requiring Penetrating and Deep Anterior Lamellar Keratoplasty. [PDF]

, 2019
PurposeMatrix metalloproteinases (MMPs) comprise a family of zinc-dependent endopeptidases involved in wound healing processes, including neovascularization and fibrosis. We assessed MMP protein expression levels in diseased corneas of patients requiring
Chan, Matilda F, Clay, Selene M, Hwang, David G, Oldenburg, Catherine E, Rose-Nussbaumer, Jennifer, Wolf, Marie   +5 more
core  

The role of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in microcystic meningiomas

Oncology Reports, 2006
We studied the expression of matrix metalloproteinases (MMP) and tissue inhibitors of matrix metalloproteinase (TIMP) in microcystic meningiomas to investigate a possible underlying mechanism for the development of microcysts and of peritumoral edema, which are frequent characteristics of this rare subtype.
Sun Ha, Paek, Dong Gyu, Kim, Chul-Kee, Park, Ji Hoon, Phi, Young Yim, Kim, Soo Young, Im, Jeong Eun, Kim, Sung-Hye, Park, Hee-Won, Jung   +8 more
openaire   +3 more sources

Matrix metalloproteinases and tissue inhibitor of metalloproteinase-1 in sarcoidosis and IPF [PDF]

European Respiratory Journal, 2002
The purpose of this study was to examine the role of interstitial collagenases, members of the family of matrix metalloproteinases, in the development of pulmonary fibrosis.The activity, levels and molecular forms of collagenases (matrix metalloproteinases (MMP)-1, -8 and -13), gelatinase B (MMP-9) and its main endogenous inhibitor, tissue inhibitor of
M T, Henry, K, McMahon, A J, Mackarel, K, Prikk, T, Sorsa, P, Maisi, R, Sepper, M X, Fitzgerald, C M, O'Connor   +8 more
openaire   +2 more sources