Results 31 to 40 of about 165,123 (342)

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]

, 2009
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher, Birchmeier, Bugge, Chirgadze, Collen, Deyi Qiu, Ellis, Ellis, Gherardi, Harris, Herter, Høyer-Hansen, Itoh, Jennifer L. Harris, Juliano Alves, Jun Li, Kate A. Owen, Ke, Kemp, Kilpatrick, Kirchhofer, Kirchhofer, Lamszus, Lee, Lynette M. Kilpatrick, Mangel, Marcotte, Mars, Mars, Matsuoka, Miyazawa, Mizuno, Mohammed, Naldini, Naldini, Qiu, Rahman, Riddick, Schmidt, Shanmukhappa, Shimizu, Shimomura, Steinmetzer, Stephens, Takeuchi, Uehara, Vincent Ellis, You   +47 more
core   +3 more sources

Neuroimmunomodulatory effects of transcranial laser therapy combined with intravenous tPA administration for acute cerebral ischemic injury

Neural Regeneration Research, 2015
At present, the only FDA approved treatment for ischemic strokes is intravenous administration of tissue plasminogen activator within 4.5 hours of stroke onset.
Philip V Peplow
doaj   +1 more source

HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]

, 2015
The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone, Caruso, Maria, Galdieri, Michela, Ricci, Giulia, Rita, Canipari, Scheri, Katia Corano, Virginia, Di Paolo   +6 more
core   +1 more source

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Plasminogen Activator – Multifunctional Protein of Plague Pathogen

Проблемы особо опасных инфекций, 2016
Yersinia pestis plasminogen activator, a surface protease (Pla) is encoded by species-specific plasmid pPla. This enzyme belongs to outer membrane protein family and has a ß-barrel structure.
L. M. Kukleva, A. V. Boiko
doaj   +1 more source

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial [PDF]

, 2009
<br>Background: Metformin reduces cardiovascular risk in patients with type 2 diabetes seemingly independent of lowering blood glucose concentration. We assessed the cardiovascular effects of metformin in individuals without type 2 diabetes.</br&
Eddy, Despres, Grundy, Bird, Seifarth, Nathan, Fontbonne, Charles, Holman, Kooy, Knowler, Alberti, Vergeer, Touboul, Liang, Spence, Levey, Meaney, Taylor, Selvin, Boussageon, Sjöström, Shyangdan, de Jager, Bots, Taylor, Boden, Huang, Baigent, Lorenz, Mazzone, Taylor, Lonn, Lexis   +33 more
core   +5 more sources

Evaluation of coagulation activation after Rhinovirus infection in patients with asthma and healthy control subjects: an observational study [PDF]

, 2014
Background Asthma exacerbations are frequently triggered by rhinovirus infections. Both asthma and respiratory tract infection can activate haemostasis. Therefore we hypothesized that experimental rhinovirus-16 infection and asthmatic airway inflammation
Bel, EHD, De Pol, MAV, Johnston, SL, Kamphuisen, PW, Lutter, R, Majoor, CJ, Meijers, JCM, Molenkamp, R, Nieuwland, R, Sterk, PJ, Van der Poll, T, Van der Sluijs, KF, Wolthers, KC   +12 more
core   +11 more sources

Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway

Neural Regeneration Research
Recombinant tissue plasminogen activator is commonly used for hematoma evacuation in minimally invasive surgery following intracerebral hemorrhage. However, during minimally invasive surgery, recombinant tissue plasminogen activator may come into contact
Jie Jing, Shiling Chen, Xuan Wu, Jingfei Yang, Xia Liu, Jiahui Wang, Jingyi Wang, Yunjie Li, Ping Zhang, Zhouping Tang   +9 more
doaj   +1 more source

Plasminogen influence on the PAI-1 release by human platelets [PDF]

The Ukrainian Biochemical Journal
РАІ-1 (plasminogen activator inhibitor type 1), as a major physiological inhibitor of tissue plasminogen activator and urokinase, plays a key role in the regulation of fibrinolysis in vivo.
O. I. Yusova , T. V. Grinenko, T. F. Drobot’ko , A. O. Tykhomyrov   +3 more
doaj   +1 more source