Results 201 to 210 of about 413,621 (336)

Immunogenicity and safety of the domestic and imported live-attenuated varicella vaccine in healthy Chinese populations: a systematic review and meta-analysis. [PDF]

BMC Infect Dis
Yuan Y, Wang T, Xia Y, Shi Z, He P.
europepmc   +1 more source

Ultrasound‐Mediated Biotransfection of Engineered Bone Marrow Mesenchymal Stem Cells in Treated Bone Defects through Intracellular Cavitation

Advanced Science, EarlyView.
Ultrasound‐mediated biotransfection through intracellular cavitation increases plasmid nuclear translocation and gene transfection efficiency by 284.7% and 131.6% in engineered bone marrow mesenchymal stem cells (BMSCs) compared to traditional ultrasound‐targeted microbubble destruction techniques. The maintained bone morphogenetic protein 2 expression
Zhili Xu, Huijuan Xin, Yu Wang, Renhao Xu, Yanni He, Meijun Zhou, Zhengqiang Yuan, Hongmei Liu   +7 more
wiley   +1 more source

Predictive models of influenza A virus lethal disease yield insights from ferret respiratory tract and brain tissues. [PDF]

Sci Rep
Kieran TJ, Sun X, Maines TR, Belser JA.
europepmc   +1 more source

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

Response to primary canine core vaccination in 10-month-old seronegative dogs treated with three times the recommended therapeutic dose of Ilunocitinib tablets (Zenrelia™). [PDF]

BMC Vet Res
Fent GM, Despa S, Gabor L, Earll M, McCandless EE, O'Kelley S, Patch JR, Snyder J, King S.   +8 more
europepmc   +1 more source

On the Agglutinin Titers of Normal Human Sera. II

, 1955
Tanemoto FURUHATA, Takeo Iida, Toshiyuki Seki, Masashi HORIUCHI, Hisashi HASEBE, Tadaho MURAO   +5 more
openalex   +2 more sources

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Automated <i>Mycoplasma genitalium</i> molecular macrolide resistance detection and nucleic acid target semi-quantitation: patient demographic considerations. [PDF]

Microbiol Spectr
Moore J, Krueger T, Zapp A, Lavey SC, Munson KL, Stafford IA, Newcomb ME, Mustanski B, Munson E.   +8 more
europepmc   +1 more source

A Human Immuno‐Lung Organoid Model to Study Macrophage‐Mediated Lung Cell Senescence Upon SARS‐CoV‐2 Infection

Advanced Science, EarlyView.
Immuno‐lung organoids are developed and used spatial transcriptomics to uncover how proinflammatory macrophages drive lung cell senescence via the THBS1–(ITGA3+ITGB1) axis in COVID‐19. To ensure broad accessibility, LungSpatialDB is created, an AI‐powered data portal, enabling intuitive exploration of spatial data and biological insights through ...
Yuling Han, Dongliang Leng, Tuo Zhang, Jian Ge, Yinshan Fang, Tiankun Lu, Xue Dong, Manoj S Nair, Neranjan de Silva, Zhaowei Han, Tiancheng Jiao, Yuanhao Huang, Meiqi Zhao, Anjali Saqi, Hanina Hibshoosh, Zihe Meng, Jenny Z Xiang, Chendong Pan, Yanjie Sun, David D. Ho, Todd Evans, Jie Liu, Liuliu Yang, Jianwen Que, Shuibing Chen   +24 more
wiley   +1 more source

The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation. [PDF]

, 1967
Cerilli, GJ, Iwasaki, Y, Marchioro, TL, Porter, KA, Starzl, TE   +4 more
core   +1 more source