Results 61 to 70 of about 13,884 (201)

CONDUCTIVITY TITRATION OF GELATIN SOLUTIONS WITH ACIDS [PDF]

open access: yesJournal of General Physiology, 1923
Titrations have been made, by the conductivity method, of gelatin solutions with hydrochloric and sulphuric acids. The results indicate an end-point at about 8.6 cc. of N/10 acid per gm. of gelatin, or a combining weight of about 1,160. These results are in fair agreement with those previously obtained by the hydrogen electrode method. Better agreement
openaire   +2 more sources

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

open access: yesSmart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang   +8 more
wiley   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid   +9 more
wiley   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

Seasonal changes of some physical-chemical characteristics of milk from Dalmatian Pramenka ewes

open access: yesMljekarstvo, 2012
The aim of this study was to evaluate the influence of year and season on milk fat content and physical properties (titratable acidity, pH value, freezing point, density) of ewe’s milk.
Lidija Sajko-Matutinović   +6 more
doaj  

Erosive potential of sugar-free hard candies dissolved in water and artificial saliva

open access: yesBrazilian Journal of Oral Sciences, 2016
Aim: To compare the acidity of sugar-free hard candies dissolved in water and artificial saliva. Methods: Sugar-free Flopi Florestal hard candies (grape, strawberry, cherry, orange, ginger, lemon balm, fennel) were selected and grouped in 2 groups: G-1 (
Maria Mercês Aquino Gouveia Farias   +4 more
doaj   +1 more source

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

open access: yesThe FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

Ploidy‐dependent modulation of DNA replication kinetics in Xenopus

open access: yesThe FEBS Journal, EarlyView.
Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash   +4 more
wiley   +1 more source

Partial defoliation improves must quality of cv. Albariño infected by Grapevine leafroll associated virus 3

open access: yesPhytopathologia Mediterranea, 2012
The effect of leaf removal treatments around vine cluster zones on must quality were tested during 2003 and 2004 in Rías Baixas (Spain) in two Albariño vineyards infected by GLRaV-3.
Sonia PEREIRA-CRESPO   +3 more
doaj   +1 more source

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