The dynamics of cytokine d nitric oxide secretion in mice injected with Tityus serrulatus scorpion venom [PDF]
Mediators of Inflammation, 2002 Aims: The effects of Tityus serrulatus venom (TSV) were analysed with respect to the susceptibility of four isogenic mouse, the symptoms following injection of venom and the inflammatory mediators in an experimental model of severe envenomation induced ...
Vera L. Petricevich, Carlos F. Peña
doaj +8 more sources
Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2015 Tityus serrulatus scorpion venom (TsV) contains toxins that act on K(+) and Na(+) channels and account for the venom's toxic effects. TsV can activate murine peritoneal macrophages, but its effects on human lymphocytes have been poorly investigated. Considering that lymphocytes may play an important role in envenomation, we assessed whether TsV affects
Casella-Martins, Andrea +9 more
core +9 more sources
Selected to survive and kill: Tityus serrulatus, the Brazilian yellow scorpion. [PDF]
PLoS ONE, 2019 Annually, more than 1.2 million scorpion stings and more than 3,000 deaths occur worldwide. Tityus serrulatus Lutz and Mello, 1922 (Scorpiones, Buthidae) is the most medically relevant species in Brazil where it is spreading rapidly and causing over 90 ...
Ricardo José Gonzaga Pimenta +6 more
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Insights into the Hypertensive Effects of Tityus serrulatus Scorpion Venom: Purification of an Angiotensin-Converting Enzyme-Like Peptidase [PDF]
Toxins, 2016 The number of cases of envenomation by scorpions has grown significantly in Brazil since 2007, with the most severe cases being caused by the Tityus serrulatus scorpion. Although envenomed patients mostly suffer neurotoxic manifestations, other symptoms,
Daniela Cajado-Carvalho +7 more
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Tityus serrulatus Scorpion Venom-Induced Nociceptive Responses Depend on TRPV1, Immune Cells, and Pro-Inflammatory Cytokines [PDF]
ToxinsFor centuries, researchers have been fascinated by the composition of scorpion venom and its local and systemic effects on humans. During a sting, scorpions inject peptides and proteins that can affect immune cells and neurons.
Camila R. Ferraz +13 more
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A comparative study of severe scorpion envenomation in children caused by Tityus bahiensis and Tityus serrulatus Estudo comparativo do envenenamento escorpiônico grave em crianças provocado por Tityus bahiensis e Tityus serrulatus [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 1995 From January 1984 to May 1994, 17 of 239 children under 15 years old stung by Tityus serrulatus (15.1%) or Tityus bahiensis (84.9%) presented severe envenoming. Of these 17 patients (1-11 years old; median=2 yr) 14 were stung by T.serrulatus and three by
Fábio Bucaretchi +6 more
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Effect of Tityus serrulatus venom on cytokine production and the activity of murine macrophages [PDF]
Mediators of Inflammation, Volume 11, Issue 1, Page 23-31, 2002., 2002 The purpose of this study was to investigate the effects of Tityus serrulatus venom (TSV) on murine peritoneal macrophages evaluated in terms of activation. The effects of crude TSV were analysed by detection of cytokines, oxygen intermediate metabolites (H2O2) and nitric oxide (NO) in supernatants of peritoneal macrophages.
Vera L. Petricevich
wiley +7 more sources
Electrophysiological Characterization of the Antarease Metalloprotease from Tityus serrulatus Venom [PDF]
Toxins, 2017 Scorpions are among the oldest venomous living organisms and the family Buthidae is the largest and most medically relevant one. Scorpion venoms include many toxic peptides, but recently, a metalloprotease from Tityus serrulatus called antarease was ...
Irene Zornetta +6 more
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Inhibition of Tityus serrulatus venom hyaluronidase affects venom biodistribution. [PDF]
PLoS Neglected Tropical Diseases, 2019 BackgroundThe hyaluronidase enzyme is generally known as a spreading factor in animal venoms. Although its activity has been demonstrated in several organisms, a deeper knowledge about hyaluronidase and the venom spreading process from the bite/sting ...
Bárbara Bruna Ribeiro de Oliveira-Mendes +10 more
doaj +5 more sources
The nociceptive response induced by different classes of Tityus serrulatus neurotoxins: The important role of Ts5 in venom-induced nociception [PDF]
PLoS Neglected Tropical Diseases, 2023 Scorpion sting envenomations (SSE) are feared by the intense pain that they produce in victims. Pain from SSE is triggered mainly by the presence of neurotoxins in the scorpion venom that modulates voltage-gated ion channels.
Felipe Cerni +8 more
doaj +3 more sources