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TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS [PDF]

, 2013
The study included 70 patients with a transplanted kidney and 50 healthy volunteers representing a control group. Median age of the transplanted patients was 53 years (48-58 years). Transplanted patients had been receiving an adjuvant kidney therapy for an average of 4 years (2-6 years).
Glavaš, Josipa, Sesar, Sanda, Alkhamis, Tamara, Kralik, Kristina, Prlić, Damir, Barbić, Jerko   +5 more
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Cloning, expression and bioinformatics analysis of the duck TLR 4 gene

British Poultry Science, 2012
1. Toll-like receptors (TLRs) are type I transmembrane proteins that play an essential role in the innate immune system. Studies on the structure and function of TLRs can be applied to the development of new approaches to control diseases of humans and animals. 2. A 3432-bp cDNA encoding duck toll-like receptor 4 (duTLR4) was cloned from duck splenic
H, Jia, G, Li, J, Li, Y, Tian, D, Wang, J, Shen, Z, Tao, J, Xu, L, Lu   +8 more
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Inhibition of TLR-4/MD-2 signaling by RP105/MD-1

Journal of Endotoxin Research, 2005
Activation of Toll-like receptor (TLR) signaling by microbial and host molecular signatures is critical to the induction of immune responses. Such signaling is, perforce, kept under tight control. We recently discovered a novel endogenous inhibitor of TLR-4 — RP105. Initially identified as a B-cell-specific molecule with a role in B-cell proliferation
Senad, Divanovic, Aurelien, Trompette, Sowsan F, Atabani, Rajat, Madan, Douglas T, Golenbock, Alberto, Visintin, Robert W, Finberg, Alexander, Tarakhovsky, Stefanie N, Vogel, Yasmine, Belkaid, Evelyn A, Kurt-Jones, Christopher L, Karp   +11 more
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TLR-4: a promising target for chemotherapy-induced peripheral neuropathy

Molecular Biology Reports
Chemotherapy-induced peripheral neuropathy (CIPN) affects a significant majority of cancer patients, with up to 80% experiencing this severe and dose-limiting side effect while undergoing anti-cancer treatment. CIPN can be induced by a variety of drugs commonly employed in the management of both solid tumors and hematologic cancers. The inadequacies in
Nagendra, Babu, Anagha, Gadepalli, , Akhilesh, Dilip, Sharma, Anurag Kumar, Singh, Deepak, Chouhan, Somesh, Agrawal, Vinod, Tiwari   +7 more
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Hyaluronan differently modulates TLR‐4 and the inflammatory response in mouse chondrocytes

BioFactors, 2012
AbstractHyaluronic acid (HA) may exert different action depending on its degree of polymerization. Small HA fragments induce proinflammatory responses, while highly polymerized HA exerts a protective effect in inflammatory pathologies such as rheumatoid arthritis.
CAMPO, Giuseppe Maurizio, AVENOSO, Angela, D'ASCOLA, ANGELA, Prestipino V, Scuruchi M, Nastasi G, CALATRONI, Alberto, CAMPO, Salvatore Giuseppe   +7 more
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Schisandra polysaccharide evokes immunomodulatory activity through TLR 4-mediated activation of macrophages

International Journal of Biological Macromolecules, 2014
Schisandra chinensis (Turcz.) Baill has been used in traditional Chinese medicine for centuries. Previous studies have shown that Schisandra polysaccharide (SCPP11) has robust antitumor activity in vivo. In this study, the immunomodulatory activity and mechanisms of action of SCPP11 were investigated further to reveal its mechanism of action against ...
Ting, Zhao, Yun, Feng, Jing, Li, Riwen, Mao, Ye, Zou, Weiwei, Feng, Daheng, Zheng, Wei, Wang, Yao, Chen, Liuqing, Yang, Xiangyang, Wu   +10 more
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Adsorbed Fibrinogen stimulates TLR-4 on monocytes and induces BMP-2 expression

Acta Biomaterialia, 2017
Modulation of inflammatory responses to implanted biomaterials towards tissue regeneration has gained prominence as an innovative tissue engineering strategy. Recent in vitro and in vivo studies showed that Fibrinogen (Fg) adsorbed to Chitosan (Ch) substrates modulates immune cell responses, enhances the production of osteogenic factors by monocytes ...
Marta I, Oliveira, Marta L, Pinto, Raquel M, Gonçalves, M Cristina L, Martins, Susana G, Santos, Mário A, Barbosa   +5 more
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Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis

Molecular and Cellular Biochemistry, 2008
Curcumin, an active ingredient of Curcumin longa mediates its anti-inflammatory effects through inhibition of NFkB. Several pathways including toll-like receptors (TLR) induce NFkB leading to inflammation. In this study, we investigated the effects of curcumin on the expression of TLR-4 and MyD88, the upstream signaling pathway in experimental colitis ...
A, Lubbad, M A, Oriowo, I, Khan
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Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.

The American journal of pathology, 2003
Acute lung injury (ALI) leading to respiratory distress is a common sequela of shock/trauma, however, modeling this process in mice with a single shock or septic event is inconsistent. One explanation is that hemorrhage is often just a "priming insult," thus, secondary stimuli may be required to "trigger" ALI.
Alfred, Ayala, Chun-Shiang, Chung, Joanne L, Lomas, Grace Y, Song, Lesley A, Doughty, Stephen H, Gregory, William G, Cioffi, Brian W, LeBlanc, Jonathan, Reichner, H Hank, Simms, Patricia S, Grutkoski   +10 more
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Investigating TLR-4 signalling in response to protein ligands

2018
Toll-like receptor (TLR)-4 is a pattern recognition receptor (PRR) that recognises the pathogen-associated molecular pattern (PAMP) lipopolysaccharide (LPS) produced by Gram-negative bacteria. LPS binds to Myeloid differentiation 2 (MD-2)/TLR-4 heterodimers, driving their dimerisation and inducing a conformational change of the intracellular TLR-4 toll/
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