Randomized controlled trial of vitamin d supplementation on toll-like receptor-2 (tlr-2) and toll-like receptor-4 (tlr-4) in tuberculosis spondylitis patients [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background Tuberculosis spondylitis accounts for approximately 50% of all cases of skeletal tuberculosis. Vitamin D plays a role in the immune system. Vitamin D helps in the activation of TLR-2 and TLR-4, which play a role in the process of tuberculosis ...
Jainal Arifin +5 more
doaj +2 more sources
TLR‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis
Jornal de Pediatria (Versão em Português), 2014 Objective: To analyze toll‐like receptor (TLR)‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis. Methods: This prospective study included 27 full‐term newborns aged 8 to 29 days, with clinical and laboratory diagnosis of late‐onset ...
Ana C.C. Redondo +6 more
doaj +8 more sources
Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis. [PDF]
Dis Markers, 2020 Background. Periodontitis is a kind of chronic infectious disease, affecting the health of billions of people. In recent years, a number of studies have shown that multiple immune gene polymorphisms are associated with the susceptibility to periodontitis, among which TLR-2 plays a critical role in periodontitis.
Shan C +4 more
europepmc +4 more sources
Regulation of CAMP (cathelicidin antimicrobial peptide) expression in adipocytes by TLR 2 and 4. [PDF]
Innate Immun, 2021 Recent data argue for a pro-inflammatory role of CAMP (cathelicidin antimicrobial peptide) in adipocytes and adipose tissue (AT) and for regulatory circuits involving TLRs. In order to investigate regulatory effects of TLR2 and TLR4, 3T3-L1 adipocytes were stimulated with TLR2 agonistic lipopeptide MALP-2 and with TLR4 agonist LPS in presence or ...
Höpfinger A +3 more
europepmc +5 more sources
Fonsecaeapedrosoi Conidia and Hyphae Activate Neutrophils Distinctly: Requirement of TLR-2 and TLR-4 in Neutrophil Effector Functions [PDF]
Frontiers in Immunology, 2020 Chromoblastomycosis is a chronic and progressive subcutaneous mycosis caused mainly by the fungus Fonsecaea pedrosoi. The infection is characterized by erythematous papules and histological sections demonstrating an external layer of fibrous tissue and ...
Leandro Carvalho Dantas Breda +11 more
doaj +2 more sources
CP91110P: A Computationally Designed Multi-Epitope Vaccine Candidate for Tuberculosis via TLR-2/4 Synergistic Immunomodulation [PDF]
BiologyBackground: Tuberculosis (TB) remains a global health priority, with current interventions like the Bacille Calmette–Guérin (BCG) vaccine lacking efficacy against latent infection and drug-resistant strains.
Yajing An +9 more
doaj +2 more sources
Effects of toll like receptor 4 (TLR4) and toll like receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients [PDF]
Frontiers in ImmunologyIntroductionIn this retrospective study, it was aimed to evaluate effects of Toll Like Receptor 4 (TLR4) and Toll Like Receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients.MethodsA total of 108 acute non ...
Ender Anılır +2 more
doaj +2 more sources
Elevated Seminal Plasma TLR-2 Levels are Associated with Leukocytospermia
Dubai Medical JournalIntroduction: Leukocytospermia is associated with male infertility, but its underlying mechanisms are not fully understood. This study aimed to investigate the association between seminal plasma toll-like receptor 2 (TLR-2) and prostaglandin E2 (PGE2 ...
Rehab Sh. Al-Maliki
doaj +2 more sources
Hyperresponsiveness of Corticoid-Resistant Th17/Tc-17 Cells to TLR-2 and TLR-4 Ligands is a Feature of Multiple Sclerosis Patients at Higher Risk of Therapy Failure [PDF]
Journal of Inflammation ResearchJoana Hygino,1,* Marisa C Sales,2,* Priscila M Sacramento,1 Taissa M Kasahara,3 Júlio César Costa da Silva,3 Rafaela Bilhão,3 Regis M Andrade,4 Cláudia Cristina Ferreira Vasconcelos,1 Cleonice AM Bento1,3– 5 1Post-Graduate Program in Neurology ...
Hygino J +8 more
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Inflammation, 2010 Amyloidosis is the major complication of familial Mediterranean fever (FMF). Toll-like receptors (TLR) are involved in the activation of an innate immune system TLR-2 and TLR-4 recognize lipoteichoic acid and lipopolysaccharides (LPS), respectively.
Alper Soylu, Halil Ates, Sultan Cingoz
exaly +5 more sources