Results 31 to 40 of about 17,805,524 (287)
Journal of International Clinical Dental Research Organization, 2010 Background: Periodontitis is a common bacterial infection precipitated by exaggerated host responses to the oral microorganisms, As the first cells to encounter the oral pathogens the gingival epithelial cells (GEC) respond via toll-like receptors (TLR ...
Mythily Srinivasan +2 more
doaj +1 more source
Association of GT microsatellite polymorphism in TLR 2 gene with leprosy [PDF]
BMC Infectious Diseases, 2012 Background Toll-like receptor 2 (TLR2) is critical in bringing up immune responses to mycobacterial infections. The mutations in TLR2 are known to confer susceptibility for severe infection with mycobacteria. TLR2 may diminish response to mycobacterial proteins and place individuals at risk of developing leprosy.
Suryadevara NC +4 more
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Research progress on the signaling pathways involved in the pathogenesis of acne
Pifu-xingbing zhenliaoxue zazhiAcne is a chronic cutaneous inflammatory disorder of the pilosebaceous units, affecting a large number of adolescents and adults worldwide, and its pathogenesis is still unclear.
LIU Bai, WU Jin
doaj +1 more source
Toll-like Receptors 2 and 4 and Their Mutations in Patients with Otitis Media and Middle Ear Effusion [PDF]
Clinical and Experimental Otorhinolaryngology, 2008 ObjectivesToll-like receptors (TLRs) detect microbial infections and they can directly induce innate host defense responses. TLR 2 has been shown to be primarily involved in the recognition of peptidoglycans and lipoteichoic acid of gram positive ...
Young Chan Lee +8 more
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TLR‐2 agonist enhances the development of autoimmune diabetes
The FASEB Journal, 2008 Toll‐like receptor 2 agonist (TLR2) BLP (bacterial lipoprotein, PAM3CSV‐4) was found to enhance IL‐12 and INF‐α synthesis to ameliorate Th‐2 dependent pathology in experimental asthma and to modulate the functions of CD4 + CD25 + regulatory cells. TLR‐2
Miodrag L Lukic +2 more
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, 2019 Small molecule Toll-like receptor-7 and -8 agonists (TLR-7/8a) can be used as vaccine adjuvants to induce CD8 T cell immunity but require formulations that prevent systemic toxicity and focus adjuvant activity in lymphoid tissues.
Geoffrey M. Lynn +35 more
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Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia
Journal of Neuroinflammation, 2011 Background Hypoxic-ischemic (HI) brain injury remains a major problem in newborns, resulting in increased risk of neurological disorders. Neonatal HI triggers a broad inflammatory reaction in the brain, including activation of the innate immune system ...
Naylor Andrew S +4 more
doaj +1 more source
TLR-2 and IL-17A in Chitin-Induced Macrophage Activation and Acute Inflammation [PDF]
The Journal of Immunology, 2008 Abstract Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. To test the hypothesis that chitin is an important immune modulator, we characterized the ability of chitin fragments to regulate murine macrophage cytokine production in vitro and induce acute inflammation in vivo. In this study, we show that chitin is a
Carla A, Da Silva +4 more
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TLR 2/1 interaction of pectin depends on its chemical structure and conformation
Carbohydrate Polymers, 2023 Citrus pectins have demonstrated health benefits through direct interaction with Toll-like receptor 2. Methyl-ester distribution patterns over the homogalacturonan were found to contribute to such immunomodulatory activity, therefore molecular interactions with TLR2 were studied.
Jermendi, Éva +6 more
openaire +4 more sources
Инфекция и иммунитетThe presence of preceding cardiovascular disease (CVD) is an important risk factor for the severe clinical course of COVID-19. In addition, COVID-19 is often aggravated by cardiovascular complications.
Alla V. Shevchenko +5 more
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