Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants. [PDF]
Cellular microbiology, 2011 Changes in the cell envelope composition of mycobacteria cause major changes in cytokine profiles of infected antigen presenting cells. We describe here the modulation of inflammatory responses by Mycobacterium abscessus, an emerging pathogen in cystic fibrosis. M. abscessus is able to switch from a smooth (S) to a rough (R) morphotype by the loss of a
Roux, Anne-Laure +17 more
openaire +4 more sources
Journal of Inflammation, 2018 Background Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments.
Mehdi Taghavi +8 more
doaj +1 more source
Concentrations of Cysteinyl Leukotrienes in Various Biological Fluids of Children with Bronchial Asthma, Atopic Dermatitis and Food Protein Induced Enterocolitis [PDF]
, 2019 Clinical manifestation of food allergy is characterized by polymorphic cutaneous, respiratory and gastrointestinal syndromes. Leukotrienes occupy a key place in the pathogenesis of a wide range of inflammatory diseases, including bronchial asthma ...
Haiduchyk, H. (Halyna) +1 more
core +3 more sources
Journal of International Clinical Dental Research Organization, 2010 Background: Periodontitis is a common bacterial infection precipitated by exaggerated host responses to the oral microorganisms, As the first cells to encounter the oral pathogens the gingival epithelial cells (GEC) respond via toll-like receptors (TLR ...
Mythily Srinivasan +2 more
doaj +1 more source
Association of GT microsatellite polymorphism in TLR 2 gene with leprosy [PDF]
BMC Infectious Diseases, 2012 Background Toll-like receptor 2 (TLR2) is critical in bringing up immune responses to mycobacterial infections. The mutations in TLR2 are known to confer susceptibility for severe infection with mycobacteria. TLR2 may diminish response to mycobacterial proteins and place individuals at risk of developing leprosy.
Suryadevara NC +4 more
openaire +2 more sources
Research progress on the signaling pathways involved in the pathogenesis of acne
Pifu-xingbing zhenliaoxue zazhiAcne is a chronic cutaneous inflammatory disorder of the pilosebaceous units, affecting a large number of adolescents and adults worldwide, and its pathogenesis is still unclear.
LIU Bai, WU Jin
doaj +1 more source
Toll-like Receptors 2 and 4 and Their Mutations in Patients with Otitis Media and Middle Ear Effusion [PDF]
Clinical and Experimental Otorhinolaryngology, 2008 ObjectivesToll-like receptors (TLRs) detect microbial infections and they can directly induce innate host defense responses. TLR 2 has been shown to be primarily involved in the recognition of peptidoglycans and lipoteichoic acid of gram positive ...
Young Chan Lee +8 more
doaj +1 more source
TLR‐2 agonist enhances the development of autoimmune diabetes
The FASEB Journal, 2008 Toll‐like receptor 2 agonist (TLR2) BLP (bacterial lipoprotein, PAM3CSV‐4) was found to enhance IL‐12 and INF‐α synthesis to ameliorate Th‐2 dependent pathology in experimental asthma and to modulate the functions of CD4 + CD25 + regulatory cells. TLR‐2
Miodrag L Lukic +2 more
openaire +1 more source
Multidisciplinary Consideration of Potential Pathophysiologic Mechanisms of Paradoxical Erythema with Topical Brimonidine Therapy. [PDF]
, 2016 Rosacea is a chronic inflammatory disease with transient and non-transient redness as key characteristics. Brimonidine is a selective α2-adrenergic receptor (AR) agonist approved for persistent facial erythema of rosacea based on significant efficacy and
Detmar, Michael +6 more
core +2 more sources
A review of the immunomodulating components of maternal breast milk and protection against necrotizing enterocolitis [PDF]
, 2019 Breast milk contains immunomodulating components that are beneficial to newborns during maturation of their immune system. Human breast milk composition is influenced by an infant\u27s gestational and chronological age, lactation stage, and the mother ...
Fiorentino +5 more
core +2 more sources