Results 31 to 40 of about 137,836 (151)

Research progress on the signaling pathways involved in the pathogenesis of acne

Pifu-xingbing zhenliaoxue zazhi
Acne is a chronic cutaneous inflammatory disorder of the pilosebaceous units, affecting a large number of adolescents and adults worldwide, and its pathogenesis is still unclear.
LIU Bai, WU Jin
doaj   +1 more source

Toll-like Receptors 2 and 4 and Their Mutations in Patients with Otitis Media and Middle Ear Effusion [PDF]

Clinical and Experimental Otorhinolaryngology, 2008
ObjectivesToll-like receptors (TLRs) detect microbial infections and they can directly induce innate host defense responses. TLR 2 has been shown to be primarily involved in the recognition of peptidoglycans and lipoteichoic acid of gram positive ...
Young Chan Lee, Chul Kim, Ju Sup Shim, Jae Yong Byun, Mun Suh Park, Chang Il Cha, Young Il Kim, Jin Woo Lee, Seung Geun Yeo   +8 more
doaj   +1 more source

TLR‐2 agonist enhances the development of autoimmune diabetes

The FASEB Journal, 2008
Toll‐like receptor 2 agonist (TLR2) BLP (bacterial lipoprotein, PAM3CSV‐4) was found to enhance IL‐12 and INF‐α synthesis to ameliorate Th‐2 dependent pathology in experimental asthma and to modulate the functions of CD4 + CD25 + regulatory cells. TLR‐2
Miodrag L Lukic, Eric Mensah‐Brown, Allen Shahin   +2 more
openaire   +1 more source

Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia

Journal of Neuroinflammation, 2011
Background Hypoxic-ischemic (HI) brain injury remains a major problem in newborns, resulting in increased risk of neurological disorders. Neonatal HI triggers a broad inflammatory reaction in the brain, including activation of the innate immune system ...
Naylor Andrew S, Smith Peter LP, Stridh Linnea, Wang Xiaoyang, Mallard Carina   +4 more
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TLR-2 and IL-17A in Chitin-Induced Macrophage Activation and Acute Inflammation [PDF]

The Journal of Immunology, 2008
Abstract Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. To test the hypothesis that chitin is an important immune modulator, we characterized the ability of chitin fragments to regulate murine macrophage cytokine production in vitro and induce acute inflammation in vivo. In this study, we show that chitin is a
Carla A, Da Silva, Dominik, Hartl, Wei, Liu, Chun G, Lee, Jack A, Elias   +4 more
openaire   +2 more sources

Association between toll-like receptor genes polymorphism (TLR2, TLR4, and TLR6) and SARS-CoV-2 infection in the West Siberian region of Russia

Инфекция и иммунитет
The presence of preceding cardiovascular disease (CVD) is an important risk factor for the severe clinical course of COVID-19. In addition, COVID-19 is often aggravated by cardiovascular complications.
Alla V. Shevchenko, V. F. Prokofiev, V. I. Konenkov, A. A. Karaseva, A. D. Afanaseva, I. I. Logvinenko   +5 more
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TLR 2/1 interaction of pectin depends on its chemical structure and conformation

Carbohydrate Polymers, 2023
Citrus pectins have demonstrated health benefits through direct interaction with Toll-like receptor 2. Methyl-ester distribution patterns over the homogalacturonan were found to contribute to such immunomodulatory activity, therefore molecular interactions with TLR2 were studied.
Jermendi, Éva, Fernández-Lainez, Cynthia, Beukema, Martin, López-Velázquez, Gabriel, van den Berg, Marco A., de Vos, Paul, Schols, Henk A.   +6 more
openaire   +4 more sources

Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease

Clinical and Experimental Immunology, 2004
SUMMARY Toll-like receptors (TLR) are signal molecules essential for the cellular response to bacterial cell wall components. Different functional effective polymorphisms for the TLR 4 gene (Asp299Gly; Thr399Ile) and for the TLR 2 gene (Arg677Trp, Arg753Gln) have recently been described that are associated with impaired ...
M, Folwaczny, J, Glas, H-P, Török, O, Limbersky, C, Folwaczny   +4 more
openaire   +3 more sources

Induction of TLR-2 and TLR-5 expression by Helicobacter pylori switches cagPAI-dependent signalling leading to the secretion of IL-8 and TNF-α. [PDF]

PLoS ONE, 2011
Helicobacter pylori is the causative agent for developing gastritis, gastric ulcer, and even gastric cancer. Virulent strains carry the cag pathogenicity island (cagPAI) encoding a type-IV secretion system (T4SS) for injecting the CagA protein.
Suneesh Kumar Pachathundikandi, Sabine Brandt, Joseph Madassery, Steffen Backert   +3 more
doaj   +1 more source

Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study [PDF]

Iranian Journal of Immunology, 2017
Background: The incidence of ischemic reperfusion injury (IRI) in early phase post-transplantation and activation of toll-like receptor (TLR-2) and TLR-4 remarkably impact the outcome of a renal allograft. Objective: To investigate whether the expression
Morteza Hosseinzadeh, Mohsen Nafar, Pedram Ahmadpoor, Farshid Noorbakhsh, Mir Saeed Yekaninejad, Mohammad Hossein Niknam, Aliakbar Amirzargar   +6 more
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