Results 1 to 10 of about 136,566 (115)

Association of TLR-4 896A/G, TLR-4 1196C/T, and TLR-9 C/T polymorphism with schizophrenia in Indian Bengalee patient [PDF]

Indian Journal of Psychiatry, 2022
Background: Chronic low-grade inflammation triggered by viral agents is a suggested etiological factor for schizophrenia. However, the underlying mechanism of inflammation and genetic predisposition to schizophrenia is poorly understood.
Jiwan Gurung, Nirmal Kumar Bera, Manoj Lama, Bisu Singh   +3 more
doaj   +2 more sources

Randomized controlled trial of vitamin d supplementation on toll-like receptor-2 (tlr-2) and toll-like receptor-4 (tlr-4) in tuberculosis spondylitis patients [PDF]

Journal of Orthopaedic Surgery and Research, 2023
Background Tuberculosis spondylitis accounts for approximately 50% of all cases of skeletal tuberculosis. Vitamin D plays a role in the immune system. Vitamin D helps in the activation of TLR-2 and TLR-4, which play a role in the process of tuberculosis ...
Jainal Arifin, Muhammad Nasrum Massi, Karya Triko Biakto, Agussalim Bukhari, Zairin Noor, Muhammad Phetrus Johan   +5 more
doaj   +2 more sources

Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis

Frontiers in Genetics, 2023
Background: An increasing number of studies have suggested the relationship between single-nucleotide polymorphisms (SNPs) in toll-like receptor (TLR) genes and gastric cancer (GC) susceptibility; however, the available evidence is contradictory.
Ayoub Al Othaim, Sulieman Ibraheem Shelash Al-Hawary, Hashem O. Alsaab, Sami G. Almalki, Mazin A. A. Najm, Ahmed Hjazi, Ali Alsalamy, Abbas Firras Almulla, Hamzeh Alizadeh   +8 more
doaj   +1 more source

Influence of genetic variability in toll-like receptors (TLR 2, TLR 4, and TLR 9) on human immunodeficiency virus-1 disease progression

International Journal of Mycobacteriology, 2023
Background: It has been demonstrated that toll-like receptors (TLR2), TLR4, and TLR9 which were initially known for recognizing bacterial products are involved in the detection of viral components.
Gaurav Kaushik, Richa Vashishtha
doaj   +1 more source

Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance

Pharmaceutics, 2022
In the course of infection and intense endotoxemia processes, induction of a catabolic state leading to weight loss is observed in mice and humans. However, the late effects of acute inflammation on energy homeostasis, regulation of body weight and ...
Edson Mendes de Oliveira, Jacqueline C. Silva, Thais P. Ascar, Silvana Sandri, Alexandre F. Marchi, Silene Migliorini, Helder T. I. Nakaya, Ricardo A. Fock, Ana Campa   +8 more
doaj   +1 more source

Sophoricoside attenuates neuronal injury and altered cognitive function by regulating the LTR-4/NF-κB/PI3K signalling pathway in anaesthetic-exposed neonatal rats

Archives of Medical Science, 2020
Introduction This study examined the protective effects of sophoricoside on neuronal injury and cognitive dysfunction in anaesthetic-exposed neonatal rats.
Lihua Yang, Yucan Xu, Wei Zhang
doaj   +1 more source

Zymosan attenuates melanoma growth progression, increases splenocyte proliferation and induces TLR-2/4 and TNF-α expression in mice

Journal of Inflammation, 2018
Background Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments.
Mehdi Taghavi, Esmaeil Mortaz, Alireza Khosravi, Ghasem Vahedi, Gert Folkerts, Mohammad Varahram, Mehdi Kazempour-Dizaji, Johan Garssen, Ian M. Adcock   +8 more
doaj   +1 more source

Aggregatibacter actinomycetemcomitans modulates toll-like receptors 2 and 4 in gingival epithelial cells in experimental periodontitis

Journal of International Clinical Dental Research Organization, 2010
Background: Periodontitis is a common bacterial infection precipitated by exaggerated host responses to the oral microorganisms, As the first cells to encounter the oral pathogens the gingival epithelial cells (GEC) respond via toll-like receptors (TLR ...
Mythily Srinivasan, Krithika N Kodumudi, Dominique M Galli   +2 more
doaj   +1 more source

Platelet-derived Toll-like receptor 4 (Tlr-4) is sufficient to promote microvascular thrombosis in endotoxemia. [PDF]

PLoS ONE, 2012
Endotoxin (lipopolysaccharide, LPS) produced by gram-negative bacteria initiates a host of pro-inflammatory effects through Toll-like receptor 4 (TLR-4).
Ryan J Stark, Niloufar Aghakasiri, Rolando E Rumbaut   +2 more
doaj   +1 more source

TLR‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis

Jornal de Pediatria (Versão em Português), 2014
Objective: To analyze toll‐like receptor (TLR)‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis. Methods: This prospective study included 27 full‐term newborns aged 8 to 29 days, with clinical and laboratory diagnosis of late‐onset ...
Ana C.C. Redondo, Maria E.J.R. Ceccon, Ana L. Silveira‐Lessa, Camila Quinello, Patrícia Palmeira, Werther B. Carvalho, Magda Carneiro‐Sampaio   +6 more
doaj   +1 more source