Results 11 to 20 of about 154,777 (303)
TLR‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis
Jornal de Pediatria (Versão em Português), 2014 Objective: To analyze toll‐like receptor (TLR)‐2 and TLR‐4 expression in monocytes of newborns with late‐onset sepsis. Methods: This prospective study included 27 full‐term newborns aged 8 to 29 days, with clinical and laboratory diagnosis of late‐onset ...
Ana C.C. Redondo +6 more
doaj +7 more sources
The role of TLR-4 in chemoresistance of cancer. [PDF]
Discov OncolAbstract Chemotherapy, which aims to eradicate tumor cells and enhance patient survival, is a prevalent approach for tumor treatment. Nevertheless, recurrence and drug resistance resulting from consecutive chemotherapy regimens have emerged as significant factors contributing to the high fatality rates among cancer patients.
Li Y +5 more
europepmc +4 more sources
Subcellular organelle lipidomics in TLR-4-activated macrophages [PDF]
Journal of Lipid Research, 2010 Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization of individual lipids.
Alexander Y, Andreyev +18 more
openaire +2 more sources
TLR-4 Regulates CD8+ T Cell Trapping in the Liver [PDF]
The Journal of Immunology, 2005 Abstract Mammalian TLRs are understood primarily as an activating system for innate and adaptive immunity, but have also been implicated in sensing cellular damage and in promoting intestinal integrity. In this study we show that TLR-4 also controls the in vivo distribution of activated CD8+ T cells.
Beena, John, Ian Nicholas, Crispe
openaire +2 more sources
Protection of outbred mice against a vaginal challenge by a Chlamydia trachomatis serovar E recombinant major outer membrane protein vaccine is dependent on phosphate substitution in the adjuvant. [PDF]
, 2020 Chlamydia trachomatis is the most common bacterial sexually-transmitted pathogen for which there is no vaccine. We previously demonstrated that the degree of phosphate substitution in an aluminum hydroxide adjuvant in a TLR-4-based C. trachomatis serovar
Ausar, Salvador Fernando +7 more
core +1 more source
Journal of Inflammation, 2018 Background Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments.
Mehdi Taghavi +8 more
doaj +1 more source
Platelet-derived Toll-like receptor 4 (Tlr-4) is sufficient to promote microvascular thrombosis in endotoxemia. [PDF]
PLoS ONE, 2012 Endotoxin (lipopolysaccharide, LPS) produced by gram-negative bacteria initiates a host of pro-inflammatory effects through Toll-like receptor 4 (TLR-4).
Ryan J Stark +2 more
doaj +1 more source
TLR-4 and VEGF Polymorphisms in Chronic Periaortitis
PLoS ONE, 2013 Chronic periaortitis (CP) is a rare disease that is characterised by fibro-inflammatory tissue surrounding the abdominal aorta and has both non-aneurysmal (idiopathic retroperitoneal fibrosis [IRF]) and aneurysmal forms (inflammatory abdominal aortic aneurysm [IAAA]).
Cordula M. Stover +13 more
openaire +5 more sources
International Immunopharmacology, 2010 TLR-4 has also been identified as a receptor for endogenous alarmins, which are increased post transplantation. TLR-4 has also been associated with a polymorphism that could impact graft outcome.To assess the expression of TLR-4 in kidney transplant patients carrying or not a polymorphism.TLR-4 polymorphism (A299G/T399I) was studied in 200 renal ...
Nogueira, Eliana UNIFESP +7 more
openaire +3 more sources
Medical Journal of Babylon, 2023 Background: Empagliflozin is an antidiabetic medication having anti-inflammatory and antioxidant properties. Objectives: To develop a chronic unpredictable stress (CUS) model in male rats, evaluate empagliflozin’s antidepressant effects, and describe the
Hatem Kareem Mijwel +2 more
doaj +1 more source