Results 41 to 50 of about 13,006,177 (289)

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

The Effect of TLR4 Asp299Gly polymorphism on IL-6 and IL -18 expression in H.pylori infected patients [PDF]

Journal of Kerman University of Medical Sciences, 2016
Background & Aims: Helicobacter pylori (H. pylori) infection is associated with peptic ulcer and gastric cancer. Polymorphisms of the genes coding Toll-like receptors (TLRs) may influence the innate and adaptive immune responses and affect the ...
Ghorbanali Rahimian, Nader Bagheri, Abolfazl Gholipour, Hedayatollah Shirzad   +3 more
doaj  

Toll-like Receptors 2 and 4 and Their Mutations in Patients with Otitis Media and Middle Ear Effusion [PDF]

Clinical and Experimental Otorhinolaryngology, 2008
ObjectivesToll-like receptors (TLRs) detect microbial infections and they can directly induce innate host defense responses. TLR 2 has been shown to be primarily involved in the recognition of peptidoglycans and lipoteichoic acid of gram positive ...
Young Chan Lee, Chul Kim, Ju Sup Shim, Jae Yong Byun, Mun Suh Park, Chang Il Cha, Young Il Kim, Jin Woo Lee, Seung Geun Yeo   +8 more
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Effects of Toll-Like Receptors 3 and 4 in the Osteogenesis of Stem Cells

Stem Cells International, 2014
Objective. To investigate the effects of Toll-like receptors in stem cell osteogenesis. Methods. Bone marrow mesenchymal stem cells (BMSCs) were divided into the blank group, the TLR-3 activated group, and the TLR-4 activated group.
Chen Qi, Xu Xiaofeng, Wang Xiaoguang
doaj   +1 more source

TLR-4 urine levels.

, 2014
Urine deriving from the same mice of the above experiments were utilized for determining levels of TLR-4, a molecule that interacts with LPS [10]. After LPS infusion, urine TLR-4 increased dramatically and then decreased in the following 72 hours.
Gian Marco Ghiggeri (336058), Roberta Bertelli (649350), Fabio Grassi (247083), Maria Pia Rastaldi (156242), Masami Ikehata (566374), Michela Cioni (649352), Alice Bonanni (649353), Armando Di Donato (649351)   +7 more
core   +1 more source

The Role of TLR-4 and Galectin-3 Interaction in Acute Pancreatitis [PDF]

Serbian Journal of Experimental and Clinical Research, 2020
Abstract Toll-like receptor-4 (TLR-4) is a member of evolutionarily conserved type I transmembrane proteins that can initiate sterile inflammatory cascade in the pancreas. Expression of TLR-4 is up-regulated in pancreatic tissue, as well as, on peripheral blood innate immune cells in human and experimental models of acute pancreatitis.
Milica Dimitrijevic Stojanovic, Bojan Stojanovic, Nebojsa Arsenijevic, Bojana Stojanovic   +3 more
openaire   +1 more source

How “Green” is Your Functional Material? Assessing Environmental Impacts of Multi‐Step Synthetic Protocols in Material Sciences at Various Technology Levels

Advanced Materials, EarlyView.
Environmental Synthesis Radar (ESR) evaluates the environmental impact of (early‐stage) multi‐step chemical syntheses, providing a holistic view by using 18 midpoint impact categories. Unlike conventional life‐cycle assessment (LCA) approaches, ESR reveals three complementary metrics: overall impact Vtotal, environmental hotspots VEF, and critical ...
Laura Plein, Alexander Schommer, Florian Dietrich, Moritz Gutsch, Heike Klesper, Kevin Schuller, Lars Jahnke, Jens Leker, Klaus Meerholz   +8 more
wiley   +1 more source

ОСОБЛИВОСТІ ПРЕМОРБІДНОГО ФОНУ ТА ПЕРЕБІГУ ПНЕВМОНІЙ ПРИ ГРИПІ В ОСІБ ІЗ ПОЛІМОРФІЗМОМ ГЕНІВ TLR-2, TLR-3, TLR-4 [PDF]

, 2013
Проаналізовано преморбідний фон і перебіг грипу, ускладненого пневмонією, у пацієнтів із поліморфізмом Arg753Gln гену TLR-2, Leu412Phe гену TLR-3, Asp299Gly гену TLR-4.
Прийменко, Н.О.
core   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source