Results 31 to 40 of about 13,006,177 (289)

Effect of Pharmacological Blocking of TLR-4 on Osteoarthritis in Mice [PDF]

Journal of Arthritis, 2015
Receptors for Advanced Glycation End Products (RAGE) and Toll Like Receptor 4 (TLR-4) have been shown to play a role in the development of Osteoarthritis (OA). We have previously shown that knocking out RAGE in mice slows the disease progression in articular cartilage of the knee.
Matthew Siebert Spencer K, Wilhelm Jeffrey Z Kartchner   +1 more
openaire   +1 more source

Benificial effect of stachydrine on the traumatic brain injury induced neurodegeneration by attenuating the expressions of Akt/mTOR/PI3K and TLR4/NFκ-B pathway

Translational Neuroscience, 2018
Present investigation aims to explore the protective effect of stachydrine against traumatic brain injury (TBI) and also investigate the molecular mechanism of its action. TBI was induced by the fall a hammer (450 g) from the height of 1.5 m.
Yu Nianzu, Hu Si, Hao Zheng
doaj   +1 more source

Effects of Separate and Concomitant TLR-2 and TLR-4 Activation in Peripheral Blood Mononuclear Cells of Newborn and Adult Horses. [PDF]

PLoS ONE, 2013
Deficient innate and adaptive immune responses cause newborn mammals to be more susceptible to bacterial infections than adult individuals. Toll-like receptors (TLRs) are known to play a pivotal role in bacterial recognition and subsequent immune ...
Johannes Cornelis Vendrig, Luc Edgar Coffeng, Johanna Fink-Gremmels   +2 more
doaj   +1 more source

Toll-like receptor expression in C3H/HeN and C3H/HeJ mice during Salmonella enterica serovar Typhimurium infection [PDF]

, 2003
Here, we have investigated the mRNA expression of Toll-like receptor 2 (TLR-2), TLR-4, and MD-2 in spleens and livers of C3H/HeN mice (carrying wild-type TLR-4) and C3H/HeJ mice (carrying mutated TLR-4) in response to Salmonella infection.
Maskell, Duncan J, Foster, Neil, Tötemeyer, Sabine, Kaiser, Pete, Bryant, Clare E   +4 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Coxiella burnetii lipopolysaccharide blocks p38α-MAPK activation through the disruption of TLR-2 and TLR-4 association

Frontiers in Cellular and Infection Microbiology, 2015
To survive in macrophages, Coxiella burnetii hijacks the activation pathway of macrophages. Recently, we have demonstrated that C. burnetii, via its lipopolysaccharide (LPS), avoids the activation of p38α-MAPK through an antagonistic engagement of Toll ...
Filippo eConti, Nicolas eBoucherit, Veronica eBaldassarre, Virginie eTrouplin, Giovanna eMottola, Rudolf eToman, Jean-louis eMege, Eric eGhigo   +7 more
doaj   +1 more source

TLR-4/Wnt modulation as new therapeutic strategy in the treatment of glioblastomas [PDF]

Oncotarget, 2018
Glioblastomas are highly aggressive brain tumors. Various pathways are involved in gliomagenesis, among which the Wingless (Wnt) signaling. Dickkopf protein-related protein 3 (Dkk-3) interacts with proteins of Wnt pathwayas inhibitor. The Wnt signaling contributes to activity of the claudins, that are critical components of tight junctions, whose ...
Casili, Giovanna, Caffo, Maria, Campolo, Michela, Barresi, Valeria, Caruso, Gerardo, Cardali, Salvatore M, Lanza, Marika, Mallamace, Raffaella, Filippone, Alessia, Conti, Alfredo, Germanò, Antonino, Cuzzocrea, Salvatore, Esposito, Emanuela   +12 more
openaire   +4 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Impact of Polymer-TLR-7/8 Agonist (Adjuvant) Morphology on the Potency and Mechanism of CD8 T Cell Induction

, 2019
Small molecule Toll-like receptor-7 and -8 agonists (TLR-7/8a) can be used as vaccine adjuvants to induce CD8 T cell immunity but require formulations that prevent systemic toxicity and focus adjuvant activity in lymphoid tissues.
Geoffrey M. Lynn, Karel Ulbrich (515369), Faezzah Baharom, Gray Kueberuwa (6244223), Faezzah Baharom (4093315), Amy Q. Wang (1395658), Joseph R. Francica (242197), Neeha Zaidi (6244229), Joseph R. Francica, Robert A. Seder, Andrew S. Ishizuka (6244226), Anna Lagová, Nicolas J. Blobel, Nicolas J. Blobel (6244235), Richard Laga, Neeha Zaidi, Ramiro A. Ramirez-Valdez, Anna Lagová (6244220), Andrew S. Ishizuka, Michael Y. Gerner (690623), Richard Laga (1554178), Michael Y. Gerner, Ramiro A. Ramirez-Valdez (6244232), Amy Q. Wang, Geoffrey M. Lynn (6244217), Joseph Leal (3928820), Robert A. Seder (750008), Tomáš Etrych, Tomáš Etrych (1554169), Gray Kueberuwa, Joseph Leal, Karel Ulbrich, Petr Chytil, Petr Chytil (1887454), Leonard W. Seymour, Leonard W. Seymour (9362)   +35 more
core   +1 more source

Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype [PDF]

Journal of Leukocyte Biology, 2011
ABSTRACTEicosanoid metabolism differs in profile and quantity between macrophages of different tissue origin and method of elicitation, as well as between primary and immortalized macrophages after activation with inflammatory stimuli. Using a lipidomic approach, we comprehensively analyzed the eicosanoids made by murine RPMs, TGEMs, BMDM, and the ...
Norris, Paul C, Reichart, Donna, Dumlao, Darren S, Glass, Christopher K, Dennis, Edward A   +4 more
openaire   +4 more sources