Zaporožskij Medicinskij Žurnal, 2018 The aim of the research is to establish an association between Arg753Gln polymorphism of TLR-2 gene, Leu412Phe of TLR-3 gene, Asp299Gly of TLR-4 gene and susceptibility to inflammatory diseases of the upper and lower respiratory tract and the complicated
N. O. Pryimenko +4 more
doaj +1 more source
The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker [PDF]
, 2010 Background: Colorectal cancer can be efficiently treated when found at early stages, thus the search for novel markers is of paramount importance. Since inflammation is associated with cancer progression and angiogenesis, we investigated expression of ...
Adriana Albini +10 more
core +3 more sources
LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease [PDF]
, 2015 Lipopolysaccharide (LPS) is currently considered one of the major players in non-alcoholic fatty liver disease (NAFLD) pathogenesis and progression.
Agostinelli, Laura +16 more
core +2 more sources
The Distinctive Activation of Toll-Like Receptor 4 in Human Samples with Sepsis
Cells, 2022 Clinical success of Toll-Like receptor-4 (TLR-4) antagonists in sepsis therapy has thus far been lacking. As inhibition of a receptor can only be useful if the receptor is active, stratification of patients with active TLR-4 would be desirable.
Patrick Thon +16 more
doaj +1 more source
Italian Journal of Animal Science, 2022 The goal of this study was to look into the effect of two probiotics as feed additives: Biosol (lipotropic factor containing probiotics) and/or Zemos, and to determine the best regimen for using both probiotics to improve growth performance, carcass ...
Nessma Hassan +4 more
doaj +1 more source
TLR-4 ligation of dendritic cells is sufficient to drive pathogenic T cell function in experimental autoimmune encephalomyelitis [PDF]
, 2012 Background Experimental autoimmune encephalomyelitis (EAE) depends on the initial activation of CD4+ T cells responsive to myelin autoantigens. The key antigen presenting cell (APC) population that drives the activation of naïve T cells most efficiently ...
AC Buenafe +33 more
core +2 more sources
Effect of Pharmacological Blocking of TLR-4 on Osteoarthritis in Mice [PDF]
Journal of Arthritis, 2015 Receptors for Advanced Glycation End Products (RAGE) and Toll Like Receptor 4 (TLR-4) have been shown to play a role in the development of Osteoarthritis (OA). We have previously shown that knocking out RAGE in mice slows the disease progression in articular cartilage of the knee.
Matthew Siebert Spencer K +1 more
openaire +1 more source
Concentrations of Cysteinyl Leukotrienes in Various Biological Fluids of Children with Bronchial Asthma, Atopic Dermatitis and Food Protein Induced Enterocolitis [PDF]
, 2019 Clinical manifestation of food allergy is characterized by polymorphic cutaneous, respiratory and gastrointestinal syndromes. Leukotrienes occupy a key place in the pathogenesis of a wide range of inflammatory diseases, including bronchial asthma ...
Haiduchyk, H. (Halyna) +1 more
core +3 more sources
Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis [PDF]
, 2010 Background Previously we reported that mice deficient in toll-like receptor 4 (TLR-4) signalling were protected from diet-induced non-alcoholic steatohepatitis (NASH).
Chantal A Rivera +37 more
core +1 more source
Evaluation of Toll-Like receptor 2 and 4 RNA expression and the cytokine profile in postmenopausal women with metabolic syndrome. [PDF]
PLoS ONE, 2014 OBJECTIVE: To evaluate the gene expression of Toll-Like (TLR-2 and TLR-4) receptors and cytokine profile in postmenopausal women with or without metabolic syndrome (MetS).
Claudio Lera Orsatti +5 more
doaj +1 more source