Results 21 to 30 of about 136,864 (160)

Evaluation of Toll-Like receptor 2 and 4 RNA expression and the cytokine profile in postmenopausal women with metabolic syndrome. [PDF]

PLoS ONE, 2014
OBJECTIVE: To evaluate the gene expression of Toll-Like (TLR-2 and TLR-4) receptors and cytokine profile in postmenopausal women with or without metabolic syndrome (MetS).
Claudio Lera Orsatti, Eliana Aguiar Petri Nahas, Jorge Nahas-Neto, Fabio Lera Orsatti, Vanessa Innocenti Giorgi, Steven S Witkin   +5 more
doaj   +1 more source

Role of toll-like receptor 4 in eliciting adaptive immune responses against recombinant BCG expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum

Asian Pacific Journal of Tropical Biomedicine, 2019
Objective: To determine the role of toll-like receptor 4 (TLR-4) in eliciting cellular and humoral immune responses against recombinant Mycobacterium bovis bacille Calmette-Guérin (rBCG) expressing the C-terminus of merozoite surface protein-1 of ...
Muhammad A Abbas, Rapeah Suppian
doaj   +1 more source

Effect of Pharmacological Blocking of TLR-4 on Osteoarthritis in Mice [PDF]

Journal of Arthritis, 2015
Receptors for Advanced Glycation End Products (RAGE) and Toll Like Receptor 4 (TLR-4) have been shown to play a role in the development of Osteoarthritis (OA). We have previously shown that knocking out RAGE in mice slows the disease progression in articular cartilage of the knee.
Matthew Siebert Spencer K, Wilhelm Jeffrey Z Kartchner   +1 more
openaire   +1 more source

Patterns of milk productivity associated with biochemical parameters and expressions of the HSPs and Toll Like genes in dairy buffaloes

Medicina Veterinária
The aim of this study was to verify milk productivity associated with biochemical parameters and expression of stress marker genes (HSP70, HSP90?, HSP90?) and immunity (TLR-2 and TLR-4) in dairy buffaloes.
Henrique Low Nogueira, Elem Cristina Macedo Barra de Sousa, Cintia Luana Pinheiro Santos, Ednaldo Silva Filho, Priscila Di Paula Bessa Santana   +4 more
doaj   +5 more sources

Effects of lime (Citrus aurantifolia) peel to the expression of mRNA toll-like receptors 4 in balb/c mice-infected Salmonella typhi

Journal of Advanced Pharmaceutical Technology & Research, 2020
Lime peel contains metabolic compounds that have lethal effects of bacterial cells, but its effect as an antibacterial modulate innate immunity pathways, especially toll-like receptor 4 (TLR-4) signaling pathway, is unclear.
Vivien Novarina Kasim, Mochammad Hatta, Rosdiana Natzir, Veni Hadju, Ami Febriza, Hasta Handayani Idrus   +5 more
doaj   +1 more source

Benificial effect of stachydrine on the traumatic brain injury induced neurodegeneration by attenuating the expressions of Akt/mTOR/PI3K and TLR4/NFκ-B pathway

Translational Neuroscience, 2018
Present investigation aims to explore the protective effect of stachydrine against traumatic brain injury (TBI) and also investigate the molecular mechanism of its action. TBI was induced by the fall a hammer (450 g) from the height of 1.5 m.
Yu Nianzu, Hu Si, Hao Zheng
doaj   +1 more source

Effects of Separate and Concomitant TLR-2 and TLR-4 Activation in Peripheral Blood Mononuclear Cells of Newborn and Adult Horses. [PDF]

PLoS ONE, 2013
Deficient innate and adaptive immune responses cause newborn mammals to be more susceptible to bacterial infections than adult individuals. Toll-like receptors (TLRs) are known to play a pivotal role in bacterial recognition and subsequent immune ...
Johannes Cornelis Vendrig, Luc Edgar Coffeng, Johanna Fink-Gremmels   +2 more
doaj   +1 more source

Coxiella burnetii lipopolysaccharide blocks p38α-MAPK activation through the disruption of TLR-2 and TLR-4 association

Frontiers in Cellular and Infection Microbiology, 2015
To survive in macrophages, Coxiella burnetii hijacks the activation pathway of macrophages. Recently, we have demonstrated that C. burnetii, via its lipopolysaccharide (LPS), avoids the activation of p38α-MAPK through an antagonistic engagement of Toll ...
Filippo eConti, Nicolas eBoucherit, Veronica eBaldassarre, Virginie eTrouplin, Giovanna eMottola, Rudolf eToman, Jean-louis eMege, Eric eGhigo   +7 more
doaj   +1 more source

Toll-like Receptors 2 and 4 and Their Mutations in Patients with Otitis Media and Middle Ear Effusion [PDF]

Clinical and Experimental Otorhinolaryngology, 2008
ObjectivesToll-like receptors (TLRs) detect microbial infections and they can directly induce innate host defense responses. TLR 2 has been shown to be primarily involved in the recognition of peptidoglycans and lipoteichoic acid of gram positive ...
Young Chan Lee, Chul Kim, Ju Sup Shim, Jae Yong Byun, Mun Suh Park, Chang Il Cha, Young Il Kim, Jin Woo Lee, Seung Geun Yeo   +8 more
doaj   +1 more source

The Effect of TLR4 Asp299Gly polymorphism on IL-6 and IL -18 expression in H.pylori infected patients [PDF]

Journal of Kerman University of Medical Sciences, 2016
Background & Aims: Helicobacter pylori (H. pylori) infection is associated with peptic ulcer and gastric cancer. Polymorphisms of the genes coding Toll-like receptors (TLRs) may influence the innate and adaptive immune responses and affect the ...
Ghorbanali Rahimian, Nader Bagheri, Abolfazl Gholipour, Hedayatollah Shirzad   +3 more
doaj